prikaz prve stranice dokumenta Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement
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Scientific paper - Original scientific paper
Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement
Signa Vitae, 20 (2024), 1; 35-42. https://doi.org/10.22514/sv.2024.002
Sotošek, Vlatka; Velčić Brumnjak, Sandra; Bukal, Krešimir; Papež Kinkela, Dijana; Lopac, Danijel; Gržalja, Nikola; Aralica, Merica; Batinac, Tanja; Batičić, Lara

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Sotošek, V., Velčić Brumnjak, S., Bukal, K., Papež Kinkela, D., Lopac, D., Gržalja, N. ... Batičić, L. (2024). Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement. Signa Vitae, 20. (1), 35-42. doi: 10.22514/sv.2024.002

Sotošek, Vlatka, et al. "Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement." Signa Vitae, vol. 20, no. 1, 2024, pp. 35-42. https://doi.org/10.22514/sv.2024.002

Sotošek, Vlatka, Sandra Velčić Brumnjak, Krešimir Bukal, Dijana Papež Kinkela, Danijel Lopac, Nikola Gržalja, Merica Aralica, Tanja Batinac and Lara Batičić. "Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement." Signa Vitae 20, no. 1 (2024): 35-42. https://doi.org/10.22514/sv.2024.002

Sotošek, V., et al. (2024) 'Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement', Signa Vitae, 20(1), pp. 35-42. doi: 10.22514/sv.2024.002

Sotošek V, Velčić Brumnjak S, Bukal K, Papež Kinkela D, Lopac D, Gržalja N, and sur.. Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement. Signa Vitae [Internet]. 2024 [cited 2024 December 31];20(1):35-42. doi: 10.22514/sv.2024.002

V. Sotošek, et al., "Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement", Signa Vitae, vol. 20, no. 1, pp. 35-42, 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:904296. [Accessed: 31 December 2024]

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Metadata
Title (english)Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks attenuate the stress-induced response in patients during the early postoperative period following total knee replacement
AuthorVlatka Sotošek
AuthorSandra Velčić Brumnjak
AuthorKrešimir Bukal
AuthorDijana Papež Kinkela
AuthorDanijel Lopac
AuthorNikola Gržalja
AuthorMerica Aralica
AuthorTanja Batinac
AuthorLara Batičić
Author's institution(Clinical Hospital Center Rijeka)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Orthopedics and Physical Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Invasive surgical procedures cause immune system downregulation by inducing a profound proinflammatory response. Establishing the most effective type of postoperative analgesia is crucial to maintain the equilibrium of the immune system. The purpose of this research was to evaluate the influence of epidural analgesia, peripheral nerve blockade as well as systemic analgesia on stress response in patients during the early postoperative period following total knee replacement. In total, 60 patients undergoing total knee replacement were allocated into three groups (n = 20, per group) in this prospective randomized study. Group 1, Group 2 and Group 3 received epidural analgesia, sciatic and femoral peripheral nerve blocks and systemic analgesia, respectively. Intensity of pain was measured at rest and upon movement. Blood samples were collected at baseline (T0), immediately before (T1) and after (T2) surgery, and 24 (T3) and 72 (T4) h postoperatively. The absolute number of leukocytes, concentrations of catecholamine, cortisol and C-reactive protein were determined. Patients in Group 1 and Group 2 exhibited lower pain scores than Group 3. Concentrations of cortisol and norepinephrine, but not epinephrine, were significantly lower in Group 1 and Group 2 at T2 than in Group 3. Significantly lower interleukin-1β concentrations were observed in Group 1 and Group 2 at T3 and T4 than in Group 3. Interleukin-6 concentrations were minor in Group 1 and Group 2 at T2 than in Group 3. Lumbar epidural analgesia and sciatic and femoral peripheral nerve blocks are effective analgesic techniques that reduce the acute inflammatory stress response in patients during the early postoperative period following total knee replacement.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleSigna Vitae
Numberingvol. 20, no. 1, pp. 35-42
p-ISSN1334-5605
DOIhttps://doi.org/10.22514/sv.2024.002
URN:NBNurn:nbn:hr:184:904296
Publication2024
Document URLhttps://www.signavitae.com/articles/10.22514/sv.2024.002
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-02-13 08:42:49