Background: The quality of life can be observed from the psychological, social, work and physical aspects. In patients with epilepsy, the quality od life can be imparied in all the above mentioned aspects, both due to the severity and frequency of epileptic seizures, and due to the use and side effects of antiepileptic drugs. Drug-resistant epilepsy is a form of epilepsy in which with at least two optimally selected and regularly taken antiepileptics, at an appropriate dose, the complete release of epileptic seizures has not occurred. It is estimated that 30 – 40 % of epilepsy patients have been resistant to pharmacotherapy and are unsatisfactorily treated, for which the quality of life in these patients is significantly impaired. Resective neurosurgical treatment or minimally invasive neurosurgical treatment are methods of choice for the treatment of patients with drug-resistant epilepsy. Objectives: The aim of this study was to examine the impact of neurosurgical treatment and the quality of life in patients with drug-resistant epilepsy before and one year after neurosurgical treatment. Patients and Methods: The research was performed at the Referral Centre for Epilepsy, Department of Neurology, University Hospital Centre Zagreb from February 2015 to February 2020. The study included 96 patients with drug-resistant epilepsy who were examined for the quality of life before and one year after neurosurgical treatment, using the form questionnaire "Quality of life in epilepsy" (QOILE-31) validated Croatian 1.0 version and the questionnaire to assess the degree of depression "Beck Depression Inventory I" (BDI I) validated Croatian version. Results: Out of 96 patients with drug-resistant epilepsy one year after neurosurgical treatment, 46 (47.9 %) patients remained without epileptic seizures, ie „seizure free“. The mean value of the total number of seizures per month before neurosurgical treatment was 30.7 ( 49.1), and one year after neurosurgical treatment it was significantly lower, 13.3 ( 32.2). The decrease in the frequency of epileptic seizures one year after neurosurgical treatment had a statistically significant effect (p<0.05) ) on the experience of a better quality of life in 5 categories of QOLIE-31: seizure worry, overall quality of life, cognitive functioning, medication effects and social functioning. It also affected the total score QOLIE-31 and in BDI-I. Wilcoxon equivalent pair test showed that the number of antiepileptic drugs used was one year after neurosurgical treatment significantly lower (p 0.0007). Conclusion: Based on the research, it can be concluded that neurosurgical treatment in patients with drug-resistant epilepsy is extremely effective, which points to the need for early diagnosis of drug-resistant epilepsy, and indications for neurosurgical treatment. One year after neurosurgical treatment of patients with drug-resistant epilepsy the number of epileptic seizures and the number od previously used antiepileptic drugs are significantly reduced, or the patients are completly seizure free from epileptic seizures, which significantly improves their overall quality of life.