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Scientific paper - Case study
Endotelna disfunkcija u sepsi
Liječnički vjesnik, 145 (2023), Supp 4; 24-34. https://doi.org/10.26800/LV-145-supl4-7
Ćurko-Cofek, Božena; Batinac, Tanja; Laškarin, Gordana; Rakić, Marijana; Knežević, Danijel; Šustić, Alan; Sotošek, Vlatka; Batičić, Lara

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Ćurko Cofek, B., Batinac, T., Laškarin, G., Rakić, M., Knežević, D., Šustić, A. ... Batičić, L. (2023). Endotelna disfunkcija u sepsi. Liječnički vjesnik, 145. (Supp 4), 24-34. doi: 10.26800/LV-145-supl4-7

Ćurko Cofek, Božena, et al. "Endotelna disfunkcija u sepsi." Liječnički vjesnik, vol. 145, no. Supp 4, 2023, pp. 24-34. https://doi.org/10.26800/LV-145-supl4-7

Ćurko Cofek, Božena, Tanja Batinac, Gordana Laškarin, Marijana Rakić, Danijel Knežević, Alan Šustić, Vlatka Sotošek and Lara Batičić. "Endotelna disfunkcija u sepsi." Liječnički vjesnik 145, no. Supp 4 (2023): 24-34. https://doi.org/10.26800/LV-145-supl4-7

Ćurko Cofek, B., et al. (2023) 'Endotelna disfunkcija u sepsi', Liječnički vjesnik, 145(Supp 4), pp. 24-34. doi: 10.26800/LV-145-supl4-7

Ćurko Cofek B, Batinac T, Laškarin G, Rakić M, Knežević D, Šustić A, and sur.. Endotelna disfunkcija u sepsi. Liječnički vjesnik [Internet]. 2023 November 20 [cited 2024 November 15];145(Supp 4):24-34. doi: 10.26800/LV-145-supl4-7

B. Ćurko Cofek, et al., "Endotelna disfunkcija u sepsi", Liječnički vjesnik, vol. 145, no. Supp 4, pp. 24-34, November 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:094542. [Accessed: 15 November 2024]

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Metadata
Title (croatian)Endotelna disfunkcija u sepsi
Title (english)Endothelial dysfunction in sepsis
AuthorBožena Ćurko-Cofek
AuthorTanja Batinac
AuthorGordana Laškarin
AuthorMarijana Rakić
AuthorDanijel Knežević
AuthorAlan Šustić
AuthorVlatka Sotošek
AuthorLara Batičić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (croatian)
U fiziološkim uvjetima, endotel predstavlja dinamičku strukturu važnu u održavanju tonusa krvnih žila, regulaciji protoka krvi uz stijenke krvnih žila, vaskularne propusnosti, puteva zgrušavanja i adhezije leukocita. U sepsi, djelovanjem patogena i njihovih topljivih čimbenika dolazi do aktivacije endotela, oštećenja endotelnog glikokaliksa (EG) te pokretanja brojnih mehanizama koji imaju ključnu ulogu u razvoju i progresiji sepse. Nadalje, disfunkcija endotela i oštećenje EG ima za posljedicu snažni proupalni, prokagulacijski, proadhezivni i proapoptotični odgovor koji dovodi do disregualacije vaskularnog tonusa, povećane propusnosti krvnih žila, povećane adhezije i migracije leukocita uzrokujući razvoj šoka i višeorganskog zatajenja. U ovom preglednom radu prikazani su struktura i funkcija endotela i EG, opisani su mehanizmi njihovoga oštećenja tijekom sepse te posljedice koje nastaju njihovom disfunkcijom. Nadalje, iznijete su do sada poznate činjenice o metodama detekcije endotelne disfunkcije te mogućnostima njenog liječenja u sepsi s ciljem unapređenja liječenja septičnih bolesnika.
Abstract (english)
Under physiological conditions, the endothelium is a dynamic structure important for maintaining blood vessel tone, regulating blood flow along vessel walls, vascular permeability, coagulation pathways, and leukocyte adhesion. In sepsis, exposure to pathogens and their soluble factors leads to activation of the endothelium, damage to the endothelial glycocalyx (EG), and initiation of numerous mechanisms that play a key role in the development and progression of sepsis. In addition, endothelial dysfunction and damage to the EG result in a potent proinflammatory, procoagulant, proadhesive, and proapoptotic response, leading to dysregulation of vascular tone, increased vascular permeability, increased leukocyte adhesion and migration, and the development of shock and multiorgan failure. In this review, the structure and function of the endothelium and EG are summarized and the mechanisms of their damage during sepsis as well as the consequences of their dysfunction are described. In addition, available knowledge about the methods of detecting endothelial dysfunction and the possibilities of its treatment in sepsis are presented, with the aim of improving the treatment of septic patients.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLiječnički vjesnik
Numberingvol. 145, no. Supp 4, pp. 24-34
p-ISSN0024-3477
e-ISSN1849-2177
DOIhttps://doi.org/10.26800/LV-145-supl4-7
URN:NBNurn:nbn:hr:184:094542
Publication2023-11-20
ProjectNumber: uniri-biomed-18-40
Title (croatian): Karakterizacija endotelne disfunkcije i uloga IL-18 u razvoju ishemijsko reperfuzijske ozljede nakon kirurške revaskularizacije miokarda
Title (english): Characteristics of endothelial disfunction and the role of IL-18 in ischaemic-reperfusion injury after coronary artery bypass grafting
Leader: Vlatka Sotošek
Jurisdiction: Croatia
Funding stream: Nema
Document URLhttps://hrcak.srce.hr/310061
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-11-30 07:43:18