prikaz prve stranice dokumenta Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes
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Scientific paper - Original scientific paper
Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes
Scandinavian Journal of Clinical and Laboratory Investigation, 83 (2023), 6; 397-402. https://doi.org/10.1080/00365513.2023.2241368
Lucijanić, Marko; Krečak, Ivan; Cicic, David; Milošević, Marko; Vukoja, Damir; Kovačević, Ivona; Marasović, Ivan; Sedinić Lacko, Martina; Baković, Josip; Jonjić, Zeljko; Vasilj, Tamara; Stojić, Josip; Atic, Armin

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Lucijanić, M., Krečak, I., Cicic, D., Milošević, M., Vukoja, D., Kovačević, I. ... Atic, A. (2023). Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes. Scandinavian Journal of Clinical and Laboratory Investigation, 83. (6), 397-402. doi: 10.1080/00365513.2023.2241368

Lucijanić, Marko, et al. "Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 83, no. 6, 2023, pp. 397-402. https://doi.org/10.1080/00365513.2023.2241368

Lucijanić, Marko, Ivan Krečak, David Cicic, Marko Milošević, Damir Vukoja, Ivona Kovačević, Ivan Marasović, et al. "Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes." Scandinavian Journal of Clinical and Laboratory Investigation 83, no. 6 (2023): 397-402. https://doi.org/10.1080/00365513.2023.2241368

Lucijanić, M., et al. (2023) 'Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes', Scandinavian Journal of Clinical and Laboratory Investigation, 83(6), pp. 397-402. doi: 10.1080/00365513.2023.2241368

Lucijanić M, Krečak I, Cicic D, Milošević M, Vukoja D, Kovačević I, and sur.. Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2023 August 02 [cited 2024 December 03];83(6):397-402. doi: 10.1080/00365513.2023.2241368

M. Lucijanić, et al., "Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes", Scandinavian Journal of Clinical and Laboratory Investigation, vol. 83, no. 6, pp. 397-402, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:864292. [Accessed: 03 December 2024]

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Metadata
Title (english)Hypoosmolar and hyperosmolar COVID-19 patients are predisposed to dismal clinical outcomes
AuthorMarko Lucijanić
AuthorIvan Krečak
AuthorDavid Cicic
AuthorMarko Milošević
AuthorDamir Vukoja
AuthorIvona Kovačević
AuthorIvan Marasović
AuthorMartina Sedinić Lacko
AuthorJosip Baković
AuthorZeljko Jonjić
AuthorTamara Vasilj
AuthorJosip Stojić
AuthorArmin Atic
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We aimed to investigate the associations of hypo- and hyperosmolarity at hospital admission with clinical characteristics and outcomes in 5645 consecutive hospitalized COVID-19 patients treated at a tertiary-level institution. Serum osmolarity was calculated as 2x Na (mmol/L) + urea (mmol/L) + glucose (mmol/L), with normal range from 275 to 295 mOsm/L. Median serum osmolarity was 292.9 mOsm/L with 51.8% normoosmolar, 5.3% hypoosmolar and 42.9% hyperosmolar patients present at the time of hospital admission. Hypoosmolarity was driven by hyponatremia, and was associated with the presence of chronic liver disease, liver cirrhosis, active malignancy and epilepsy. Hyperosmolarity was driven by an increase in urea and glucose and was associated with the presence of chronic metabolic and cardiovascular comorbidities. Both hypo- and hyperosmolar patients presented with more severe COVID-19 symptoms, higher inflammatory status, and experienced higher mortality in comparison to normoosmolar patients. In multivariate analysis, hypoosmolarity (adjusted odds ratio (aOR)=1.39, p = 0.024) and hyperosmolarity (aOR = 1.9, p < 0.001) remained significantly associated with higher mortality independently of older age, male sex, higher Charlson Comorbidity Index and more severe COVID-19. Disruptions in serum osmolarity are frequent in COVID-19 patients, may be easy to detect and target therapeutically, and thus potentially moderate associateds poor prognosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian Journal of Clinical and Laboratory Investigation
Numberingvol. 83, no. 6, pp. 397-402
p-ISSN0036-5513
e-ISSN1502-7686
DOIhttps://doi.org/10.1080/00365513.2023.2241368
URN:NBNurn:nbn:hr:184:864292
Publication2023-08-02
Document URLhttps://www.tandfonline.com/doi/full/10.1080/00365513.2023.2241368
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-11-15 08:36:30