prikaz prve stranice dokumenta Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia
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Scientific paper - Original scientific paper
Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia
Wiener klinische Wochenschrift, 123 (2011), 23-24; 718-725. https://doi.org/10.1007/s00508-011-0096-7
Sotošek, Stanislav; Sotošek Tokmadžić, Vlatka; Mrakovčić-Šutic, Ines; Tomas, Maja Ilić; Dominovic, Marin; Tulić, Vera; Šutic, Ivana; Maričić, Antun; Sokolić, Jadranko; Šustić, Alan

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Sotošek, S., Sotošek Tokmadžić, V., Mrakovčić Šutic, I., Tomas, M. I., Dominovic, M., Tulić, V. ... Šustić, A. (2011). Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia. Wiener klinische Wochenschrift, 123. (23-24), 718-725. doi: 10.1007/s00508-011-0096-7

Sotošek, Stanislav, et al. "Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia." Wiener klinische Wochenschrift, vol. 123, no. 23-24, 2011, pp. 718-725. https://doi.org/10.1007/s00508-011-0096-7

Sotošek, Stanislav, Vlatka Sotošek Tokmadžić, Ines Mrakovčić Šutic, Maja Ilić Tomas, Marin Dominovic, Vera Tulić, Ivana Šutic, Antun Maričić, Jadranko Sokolić and Alan Šustić. "Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia." Wiener klinische Wochenschrift 123, no. 23-24 (2011): 718-725. https://doi.org/10.1007/s00508-011-0096-7

Sotošek, S., et al. (2011) 'Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia', Wiener klinische Wochenschrift, 123(23-24), pp. 718-725. doi: 10.1007/s00508-011-0096-7

Sotošek S, Sotošek Tokmadžić V, Mrakovčić Šutic I, Tomas MI, Dominovic M, Tulić V, and sur.. Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia. Wiener klinische Wochenschrift [Internet]. 2011 November 23 [cited 2024 October 22];123(23-24):718-725. doi: 10.1007/s00508-011-0096-7

S. Sotošek, et al., "Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia", Wiener klinische Wochenschrift, vol. 123, no. 23-24, pp. 718-725, November 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:348524. [Accessed: 22 October 2024]

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Title (english)Comparative study of frequency of different lymphocytes subpopulation in peripheral blood of patients with prostate cancer and benign prostatic hyperplasia
AuthorStanislav Sotošek
AuthorVlatka Sotošek Tokmadžić
AuthorInes Mrakovčić-Šutic
AuthorMaja Ilić Tomas
AuthorMarin Dominovic
AuthorVera Tulić
AuthorIvana Šutic
AuthorAntun Maričić
AuthorJadranko Sokolić
AuthorAlan Šustić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
PURPOSE: Benign prostatic hyperplasia (BPH) and prostate cancer (PC) are the most common urologic diseases among men over fifty and, until recently, they were considered to be caused by the impaired immune response. Despite many studies designed to investigate T-cell-based antitumor immunity, the role of innate immune cells in BPH and PC is still poorly understood. In this study the frequency of different leukocytes subpopulation in peripheral blood of BPH, PC patients and in healthy volunteers was analysed and compared. METHODS: In a cross-sectional study 60 subjects were enrolled (20 patients with BPH or with PC and 20 healthy volunteers). Peripheral blood mononuclear cells (PBMC) were isolated and the percentage of T lymphocytes, natural killer (NK) and NKT cells, as well as subsets of T lymphocytes [CD3(+)CD56(-)CD4(+), T-regs (CD4(+)CD25(+)FoxP3(+)) and CD3(+)CD56(-)CD8(+)] and NK cells (CD3(-)CD56(+dim) and CD3(-)CD56(+bright)) were analysed by flow cytometry. Intracellular content of interleukin-4 (IL-4) and interferon gamma (IFN gamma in T lymphocytes, NK and NKT cells were also detected. RESULTS: The percentage of T lymphocytes and their subsets in peripheral blood lymphocytes did not differ among investigated groups, while the frequency of Tregs was the highest in PC patients. The percentage of NK cell and their subsets did not differ among investigated groups. Negative correlation between PSA value, percentage of T lymphocytes and NK cells was observed only in PC patients. Highly positive correlation between the PSA value and the percentage of Tregs was found in PC patients. CONCLUSION: Different frequencies in distinctly lymphocyte subpopulation in peripheral blood of healthy men, BPH and PC patients could be responsible for occurrence and progression of prostatic hyperplasia or tumour. Due to the ability of tumours to suppress the cognate T cell immune response, the cells of innate immunity (NKT and Tregs) may be playing a key role in the immunopathogenesis of PC and BPH.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleWiener klinische Wochenschrift
Numberingvol. 123, no. 23-24, pp. 718-725
p-ISSN0043-5325
e-ISSN1613-7671
DOIhttps://doi.org/10.1007/s00508-011-0096-7
URN:NBNurn:nbn:hr:184:348524
Publication2011-11-23
Document URLhttp://link.springer.com/10.1007/s00508-011-0096-7
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-11-07 10:26:19