prikaz prve stranice dokumenta Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease
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Scientific paper - Original scientific paper
Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease
International Journal of Cardiology, 161 (2012), 3; 156-159. https://doi.org/10.1016/j.ijcard.2012.05.044
Marčun, Robert; Šustić, Alan; Brguljan, Pika Mesko; Kadivec, Saša; Farkaš, Jerneja; Kosnik, Mitja; Coats, Andrew J. Stewart; Anker, Stefan D.; Lainscak, Mitja

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Marčun, R., Šustić, A., Brguljan, P. M., Kadivec, S., Farkaš, J., Kosnik, M. ... Lainscak, M. (2012). Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease. International Journal of Cardiology, 161. (3), 156-159. doi: 10.1016/j.ijcard.2012.05.044

Marčun, Robert, et al. "Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease." International Journal of Cardiology, vol. 161, no. 3, 2012, pp. 156-159. https://doi.org/10.1016/j.ijcard.2012.05.044

Marčun, Robert, Alan Šustić, Pika Mesko Brguljan, Saša Kadivec, Jerneja Farkaš, Mitja Kosnik, Andrew J. Stewart Coats, Stefan D. Anker and Mitja Lainscak. "Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease." International Journal of Cardiology 161, no. 3 (2012): 156-159. https://doi.org/10.1016/j.ijcard.2012.05.044

Marčun, R., et al. (2012) 'Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease', International Journal of Cardiology, 161(3), pp. 156-159. doi: 10.1016/j.ijcard.2012.05.044

Marčun R, Šustić A, Brguljan PM, Kadivec S, Farkaš J, Kosnik M, and sur.. Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease. International Journal of Cardiology [Internet]. 2012 November [cited 2024 December 05];161(3):156-159. doi: 10.1016/j.ijcard.2012.05.044

R. Marčun, et al., "Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease", International Journal of Cardiology, vol. 161, no. 3, pp. 156-159, November 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:603111. [Accessed: 05 December 2024]

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Metadata
Title (english)Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease
AuthorRobert Marčun
AuthorAlan Šustić
AuthorPika Mesko Brguljan
AuthorSaša Kadivec
AuthorJerneja Farkaš
AuthorMitja Kosnik
AuthorAndrew J. Stewart Coats
AuthorStefan D. Anker
AuthorMitja Lainscak
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Purpose: In chronic obstructive pulmonary disease (COPD), cardiovascular system is involved but less is known about role of specific cardiac biomarkers. We aimed to investigate associations between N-terminal pro B-type natriuretic peptide (NT-proBNP) and troponin T during hospitalisation with 6-month outcome. Methods: This was a prospective study conducted in consecutive patients hospitalized for an acute exacerbation of COPD. On admission, and at discharge, NT-proBNP and troponin T were measured, and echocardiography was performed. Hospitalisations and mortality were recorded for 6 months after discharge. Results: We included 127 patients (70 ± 10 years, 70% men, GOLD III/IV 87%). Left ventricular dysfunction was detected in 70 (55%) patients and diastolic dysfunction was the most common type (53 patients-42%). NT-proBNP and troponin T were elevated on admission in 60% and 36%, and at discharge in 28% and 19% of patients. During follow-up, 53 (42%) patients were hospitalized and 17 (13%) patients died. In Kaplan Meier analysis of survival curves, NT-proBNP on admission distinguished between deceased and surviving patients (p = 0.011) whilst troponin T at discharge separated hospitalized and non-hospitalized patients (p = 0.017). The adjusted Cox proportional hazard model confirmed these findings: discharge troponin T predicted hospitalisations (hazard ratio 2.89, 95% confidence interval 1.13-7.36) and admission NT-proBNP predicted mortality (hazard ratio 4.20, 95% confidence interval 1.07-14.01). Conclusions: Elevated NT-proBNP at discharge and troponin T on admission predict outcome in patients hospitalized for an acute exacerbation of COPD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Cardiology
Numberingvol. 161, no. 3, pp. 156-159
p-ISSN0167-5273
DOIhttps://doi.org/10.1016/j.ijcard.2012.05.044
URN:NBNurn:nbn:hr:184:603111
Publication2012-11
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0167527312006560
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-11-02 09:34:58