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master's thesis
Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre
diplomski rad
2023. urn:nbn:hr:184:116071
Bačić, Josipa Antonija
University of Rijeka
Faculty of Medicine
Department of Pharmacology

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Bačić, J. A. (2023). Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:116071

Bačić, Josipa Antonija. "Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:116071

Bačić, Josipa Antonija. "Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad." Master's thesis, University of Rijeka, Faculty of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:184:116071

Bačić, J. A. (2023). 'Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 24 April 2025, https://urn.nsk.hr/urn:nbn:hr:184:116071

Bačić JA. Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2023 [cited 2025 April 24] Available at: https://urn.nsk.hr/urn:nbn:hr:184:116071

J. A. Bačić, "Potencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:184:116071

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Metadata
TitlePotencijalne interakcije lijekova u bolesnika oboljelih od nealkoholne masne bolesti jetre : diplomski rad
Title (english)Potential drug interactions in patients with non-alcoholic fatty liver disease
AuthorJosipa Antonija Bačić
MentorMarko Skelin (mentor)
MentorIvan Krečak (komentor)
Committee memberDinko Vitezić (predsjednik povjerenstva)
Committee memberKristina Pilipović (član povjerenstva)
Committee memberRenata Jurišić Grubešić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Rijeka
Defense date and country2023-06-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract
Uvod: Nealkoholna masna bolest jetre označava makrovezikularnu steatozu u ≥5 % hepatocita bez sekundarnih uzroka poput alkoholnih, medikamentoznih i infektivnih čimbenika. Lijek-lijek interakcije nastaju kada se učinak jednog lijeka promijeni učinkom drugog lijeka. Metode: Ovo retrospektivno istraživanje je provedeno u Općoj bolnici Šibensko-kninske županije. Dijagnoza NAFLD je postavljena prema kriterijima koji uključuju ultrazvučni nalaz steatoze jetre s ili bez povišenih vrijednosti... More ALT i GGT, uz isključenje ostalih jetrenih bolesti. Primarni cilj istraživanja bio je utvrditi prevalenciju DDI u bolesnika s NAFLD ovisno o stupnju kliničke značajnosti prema Lexicomp klasifikaciji. Rezultati: U 69,8 % bolesnika pronađena je barem jedna DDI, 69,8 % bolesnika imalo je barem jednu potencijalnu C interakciju, 32,6 % barem jednu potencijalnu D interakciju, a jedan (1,2 %) potencijalnu X interakciju. Najčešće identificirane interakcije bile su one vezane uz liječenje šećerne bolesti s potencijalnim sinergijskim hipoglikemijskim učinkom. Bolesnici s barem jednom DDI bili su starije životne dobi (p=0,001) i nižeg indeksa tjelesne mase (p=0,006). Postojala je statistički značajna povezanost DDI s arterijskom hipertenzijom (p=0,015), srčanim zatajenjem (p=0,037) i šećernom bolesti (p<0,001). Bolesnici s prisutnom barem jednom DDI češće su morali barem jednom posjetiti hitnu službu (75,3 % vs. 24,7 %, p=0,008) i češće su morali biti barem jednom hospitalizirani (75,4 % vs. 24,6 %, p=0,023) u odnosu na bolesnike bez DDI. Zaključak: Prevalencija DDI u bolesnika s NAFLD je visoka, a najčešće identificirani DDI bili su oni vezani za liječenje šećerne bolesti. Potrebno je poznavati DDI u bolesnika s NAFLD da bi se izbjegli potencijalni neželjeni događaji. Less
Abstract (english)
Introduction: Nonalcoholic fatty liver disease (NAFLD) stands for macrovesicular steatosis in ≥ 5% of hepatocytes without secondary causes such as alcoholic, medicinal and infectious factors. Drug-to-drug interactions(DDI) occur when the effect of one drug is changed by the effect of another drug. Methods: This retrospective study was conducted in the General Hospital of Šibenik-Knin County. The diagnosis of NAFLD was made according to criteria that included ultrasonographic... More identification of liver steatosis with or without elevated ALT and GGT values, and with the exclusion of other liver diseases. The primary goal of the study was to determine the prevalence of DDI in patients with NAFLD according to the Lexicomp classification. Results: At least one potential DDI was found in 69.8% of patients, 69.8% of patients had at least one potential C interaction, 32.6% at least one potential D interaction, and one (1,2%) potential X interaction. The most commonly identified C and D interactions were of medications used for the treatment of diabetes mellitus with synergistic hypoglycemic effects. Patients with at least one DDI were older (p=0.001), underweight (p=0.006) and more often had arterial hypertension (p=0.015), heart failure (p=0.037) and diabetes mellitus (p<0.001). Patients with at least one DDI more often had to visit the emergency department (75.3% vs. 24.7%, p=0.008) or had to be hospitalized at least once (75.4 % vs. 24.6 %, p=0.023). Conclusion: Potential DDIs were very frequent in NAFLD patients and the most frequently identified ones were those related to the treatment of diabetes mellitus. Physicians should recognize DDIs in patients with NAFLD in order to avoid potentially adverse clinical outcomes. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:116071
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-07 20:00:27
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