prikaz prve stranice dokumenta Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells
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Scientific paper - Original scientific paper
Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells
American Journal of Reproductive Immunology, 59 (2008), 5; 433-445. https://doi.org/10.1111/j.1600-0897.2008.00599.x
Laškarin, Gordana; Redžović, Arnela; Rubeša, Željka; Mantovani, Alberto; Allavena, Paola; Haller, Herman; Vlastelić, Ivan; Rukavina, Daniel

Cite this document

Laškarin, G., Redžović, A., Rubeša, Ž., Mantovani, A., Allavena, P., Haller, H. ... Rukavina, D. (2008). Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells. American Journal of Reproductive Immunology, 59. (5), 433-445. doi: 10.1111/j.1600-0897.2008.00599.x

Laškarin, Gordana, et al. "Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells." American Journal of Reproductive Immunology, vol. 59, no. 5, 2008, pp. 433-445. https://doi.org/10.1111/j.1600-0897.2008.00599.x

Laškarin, Gordana, Arnela Redžović, Željka Rubeša, Alberto Mantovani, Paola Allavena, Herman Haller, Ivan Vlastelić and Daniel Rukavina. "Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells." American Journal of Reproductive Immunology 59, no. 5 (2008): 433-445. https://doi.org/10.1111/j.1600-0897.2008.00599.x

Laškarin, G., et al. (2008) 'Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells', American Journal of Reproductive Immunology, 59(5), pp. 433-445. doi: 10.1111/j.1600-0897.2008.00599.x

Laškarin G, Redžović A, Rubeša Ž, Mantovani A, Allavena P, Haller H, and sur.. Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells. American Journal of Reproductive Immunology [Internet]. 2008 April 09 [cited 2024 November 12];59(5):433-445. doi: 10.1111/j.1600-0897.2008.00599.x

G. Laškarin, et al., "Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells", American Journal of Reproductive Immunology, vol. 59, no. 5, pp. 433-445, April 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:737446. [Accessed: 12 November 2024]

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Metadata
Title (english)Decidual Natural Killer Cell Tuning by Autologous Dendritic Cells
AuthorGordana Laškarin
AuthorArnela Redžović
AuthorŽeljka Rubeša
AuthorAlberto Mantovani
AuthorPaola Allavena
AuthorHerman Haller
AuthorIvan Vlastelić
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
ProblemDendritic cells (DC)⁄natural killer (NK) cells interactions in the deciduasof early human pregnancies were analyzedin vitro.Method of studyPhenotype, cytokine expression and⁄or cytolytic mediators’ expressionwere measured by flow cytometry in NK and DC from the freshly iso-lated decidual mononuclear cells or after their purification and co-cul-turein vitro.Proliferationof5(6)-CarboxyfluoresceindiacetateN-succinimidyl ester (CFSE)-labeled CD56+cells was analyzed by flowcytometry after the co-culture with CD1a+or CD83+DC.ResultsDecidual CD1a+cells show less mature phenotype with no expression ofCD197, lower expression of CD80 and CD86 and higher expression ofCD206 and CD195 in comparison to CD83+cells. Interleukin (IL)-15,interferon-cand tumor necrosis factor-aproductions were higher inimmature than mature DC, whereas IL-10 and IL-18 were equally pro-duced in both subpopulations. Immature DC increase perforin, FasL andTRAIL protein expression and proliferation of NK cells, but decreasetheir intracellular IL-15 production. Mature DC caused less efficient pro-liferation of NK cells, and did not affect cytokine and cytolytic mediatorexpression.ConclusionThese results suggest that decidual CD1a+cells regulate and shape NKcell function more profoundly than CD83+cells in decidua.ORIGINAL ARTICLEAmerican Journal of Reproductive Immunology59(2008) 433–445ª2008 The AuthorsJournal compilationª2008 Blackwell Munksgaard433
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 59, no. 5, pp. 433-445
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/j.1600-0897.2008.00599.x
URN:NBNurn:nbn:hr:184:737446
Publication2008-04-09
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2008.00599.x
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-06-30 09:04:27