Sepsis is a clinical syndrome and a life-threatening condition caused by an dysregulated host response to an infection in which the immune system overreacts to an infectious inflammatory stimulus and leads to systemic inflammation and tissue and organ damage. To establish the diagnosis of sepsis, the use of the SOFA scale, which objectiveizes the organ failure that occurs in septic patients, is currently recommended. In 2021, new guidelines for the treatment of septic patients were issued. The most important news in the new guidelines is that it is recommended to administer antibiotics within one hour of suspecting septic shock, or within the first three hours of suspecting sepsis without shock. Due to the connection between the lactate level and the fatal outcome of septic patients, it is recommended to use the lactate concentration as well as to monitor the lactate level during their treatment. The use of recapillarization time is also recommended for hemodynamic assessment. Balanced crystalloids are the first line of fluids for resuscitation of septic patients. In response to fluid resuscitation, the use of dynamic markers is also recommended. If it is necessary to use vasopressors, it is recommended not to delay their use until the central venous route is opened, but rather to apply them peripherally as soon as possible. Septic patients who are on vasopressors for longer than 4 hours should receive steroids in therapy. According to the 2021 guidelines, vitamin C is not recommended in septic patients.