prikaz prve stranice dokumenta A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy
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Scientific paper - Original scientific paper
A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy
European Archives of Oto-Rhino-Laryngology, 280 (2022), 3; 1381-1390. https://doi.org/10.1007/s00405-022-07668-1
Grasl, Stefan; Frommlet, Florian; Faisal, Muhammad; Marijić, Blažen; Schmid, Elisabeth; Heiduschka, Gregor; Brunner, Markus; Grasl, Matthaeus C.; Erovic, Boban M.; Janik, Stefan

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Grasl, S., Frommlet, F., Faisal, M., Marijić, B., Schmid, E., Heiduschka, G. ... Janik, S. (2022). A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy. European Archives of Oto-Rhino-Laryngology, 280. (3), 1381-1390. doi: 10.1007/s00405-022-07668-1

Grasl, Stefan, et al. "A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy." European Archives of Oto-Rhino-Laryngology, vol. 280, no. 3, 2022, pp. 1381-1390. https://doi.org/10.1007/s00405-022-07668-1

Grasl, Stefan, Florian Frommlet, Muhammad Faisal, Blažen Marijić, Elisabeth Schmid, Gregor Heiduschka, Markus Brunner, Matthaeus C. Grasl, Boban M. Erovic and Stefan Janik. "A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy." European Archives of Oto-Rhino-Laryngology 280, no. 3 (2022): 1381-1390. https://doi.org/10.1007/s00405-022-07668-1

Grasl, S., et al. (2022) 'A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy', European Archives of Oto-Rhino-Laryngology, 280(3), pp. 1381-1390. doi: 10.1007/s00405-022-07668-1

Grasl S, Frommlet F, Faisal M, Marijić B, Schmid E, Heiduschka G, and sur.. A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy. European Archives of Oto-Rhino-Laryngology [Internet]. 2022 October 01 [cited 2025 January 18];280(3):1381-1390. doi: 10.1007/s00405-022-07668-1

S. Grasl, et al., "A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy", European Archives of Oto-Rhino-Laryngology, vol. 280, no. 3, pp. 1381-1390, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:413136. [Accessed: 18 January 2025]

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Metadata
Title (english)A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy
AuthorStefan Grasl
AuthorFlorian Frommlet
AuthorMuhammad Faisal
AuthorBlažen Marijić
AuthorElisabeth Schmid
AuthorGregor Heiduschka
AuthorMarkus Brunner
AuthorMatthaeus C. Grasl
AuthorBoban M. Erovic
AuthorStefan Janik
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
Abstract Background: To create nomograms for better prediction of the oncological outcome in advanced laryngeal (LxCAs) or hypopharyngeal (HpxCAs) cancer after laryngopharyngectomy. Materials: 239 patients who underwent total laryngectomy or laryngopharyngectomy due to LxCA (52.7%) or HpxCA (47.3%) were included in this study. Based on clinical risk factors (tumor site, lymph node involvement, salvage setting), we created nomograms for prediction of disease-specific survival (DSS) and disease-free survival (DFS). Results: HpxCAs showed a higher rate of lymph node involvement (p < 0.001), a 2.47-fold higher risk of a 2nd head and neck cancer (p = 0.009) and significantly worse loco-regional control rates (p = 0.003) compared to LxCAs. Positive neck nodes and salvage procedures were associated with significantly worse outcome. Nomograms demonstrated that hypopharyngeal tumors with positive neck nodes in salvage situations had the worst oncological outcome with a 5-year DSS of 15-20%. Conclusions: The oncological outcome is worse in hypopharyngeal carcinomas and could be easily quantified by our nomograms that are based on tumor site, lymph node involvement and salvage situation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Archives of Oto-Rhino-Laryngology
Numberingvol. 280, no. 3, pp. 1381-1390
p-ISSN0937-4477
e-ISSN1434-4726
DOIhttps://doi.org/10.1007/s00405-022-07668-1
URN:NBNurn:nbn:hr:184:413136
Publication2022-10-01
Document URLhttps://link.springer.com/10.1007/s00405-022-07668-1
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-05-17 08:20:46