prikaz prve stranice dokumenta Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge
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Scientific paper - Case study
Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge
Clinical Pathology, 16 (2023); 1-7. https://doi.org/10.1177/2632010X221149978
Hadžisejdić, Ita; Klarica, Lucia; Babarović, Emina; Marijić, Blažen; Valković, Toni; Jonjić, Nives

Cite this document

Hadžisejdić, I., Klarica, L., Babarović, E., Marijić, B., Valković, T. & Jonjić, N. (2023). Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge. Clinical Pathology, 16., 1-7. doi: 10.1177/2632010X221149978

Hadžisejdić, Ita, et al. "Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge." Clinical Pathology, vol. 16, 2023, pp. 1-7. https://doi.org/10.1177/2632010X221149978

Hadžisejdić, Ita, Lucia Klarica, Emina Babarović, Blažen Marijić, Toni Valković and Nives Jonjić. "Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge." Clinical Pathology 16 (2023): 1-7. https://doi.org/10.1177/2632010X221149978

Hadžisejdić, I., et al. (2023) 'Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge', Clinical Pathology, 16, pp. 1-7. doi: 10.1177/2632010X221149978

Hadžisejdić I, Klarica L, Babarović E, Marijić B, Valković T, Jonjić N. Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge. Clinical Pathology [Internet]. 2023 January 15 [cited 2024 November 12];16:1-7. doi: 10.1177/2632010X221149978

I. Hadžisejdić, L. Klarica, E. Babarović, B. Marijić, T. Valković and N. Jonjić, "Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge", Clinical Pathology, vol. 16, pp. 1-7, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:742536. [Accessed: 12 November 2024]

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Metadata
Title (english)Primary Nodal Unclassifiable CD20 Negative Diffuse Large B-cell Lymphoma With Dual IgK and TCR Gene Rearrangement: A Diagnostic Challenge
AuthorIta Hadžisejdić
AuthorLucia Klarica
AuthorEmina Babarović
AuthorBlažen Marijić
AuthorToni Valković
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Non-Hodgkin lymphomas are most frequently classified based on the lineage marker expression. However, lymphomas with aberrant marker expression as well as monoclonal IgH/IgΚ and TCR gene rearrangements may co-exist which can be misleading and confusing. Primary CD20 negative diffuse large B-cell lymphomas (DLBCL) represent a rare entity, and they account for 1% to 3% of cases. However, some CD20 negative DLBCLs could not be classified into known variants, creating both diagnostic and therapeutic dilemma’s. Primary CD20 negative DLBCL are more likely to have a non-germinal centre subtype, a higher proliferation index, more frequent extra-nodal involvement, a poorer response, and poorer prognosis to conventional treatment compared to CD20 positive DLBCL. A 66- year-old postmenopausal lady, presented with palpable, bilateral neck lymphadenopathy and difficulty swallowing. She also had left leg lymphoedema, poor appetited, fatigue and weight loss. Her symptoms lasted approximately 1 month. After histological, immunohistochemical and clonality analysis of the lymph node the patient was diagnosed with primary nodal CD20 and PAX-5 negative DLBCL with dual immunoglobulin light-chain kappa ( IgK) and T-cell receptor ( TCR) gene rearrangement. This unusual and unique case presented a diagnostic challenge because it was CD20 and PAX-5 negative, had dual IgK and TCR gene rearrangement and, it could not be classified within the known and well established CD20 negative DLBCL variants. Describing such cases emphasises the fact that lymphomas unclassifiable within known variants of CD20 negative DLBCL do exist and that range and heterogeneity of CD20 negative DLBCL continues to evolve, and pathologist should be aware of these uncommon, atypical mature B-cell neoplasms.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical Pathology
Numberingvol. 16, pp. 1-7
p-ISSN2632-010X
e-ISSN2632-010X
DOIhttps://doi.org/10.1177/2632010X221149978
URN:NBNurn:nbn:hr:184:742536
Publication2023-01-15
Document URLhttp://journals.sagepub.com/doi/10.1177/2632010X221149978
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-05-04 10:19:27