prikaz prve stranice dokumenta Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation
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Scientific paper - Original scientific paper
Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation
Medical hypotheses, 175 (2023); 111078. https://doi.org/10.1016/j.mehy.2023.111078
Drvar, Vedrana; Legović, Dalen; Čanadi Jurešić, Gordana; Ćurko-Cofek, Božena; Kehler, Tatjana; Laškarin, Ana-Marija; Nemčić, Emilio; Laškarin, Gordana

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Drvar, V., Legović, D., Čanadi Jurešić, G., Ćurko Cofek, B., Kehler, T., Laškarin, A. M. ... Laškarin, G. (2023). Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation. Medical hypotheses, 175.. doi: 10.1016/j.mehy.2023.111078

Drvar, Vedrana, et al. "Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation." Medical hypotheses, vol. 175, 2023. https://doi.org/10.1016/j.mehy.2023.111078

Drvar, Vedrana, Dalen Legović, Gordana Čanadi Jurešić, Božena Ćurko Cofek, Tatjana Kehler, Ana Marija Laškarin, Emilio Nemčić and Gordana Laškarin. "Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation." Medical hypotheses 175 (2023). https://doi.org/10.1016/j.mehy.2023.111078

Drvar, V., et al. (2023) 'Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation', Medical hypotheses, 175. doi: 10.1016/j.mehy.2023.111078

Drvar V, Legović D, Čanadi Jurešić G, Ćurko Cofek B, Kehler T, Laškarin AM, and sur.. Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation. Medical hypotheses [Internet]. 2023 April 15 [cited 2024 May 05];175. doi: 10.1016/j.mehy.2023.111078

V. Drvar, et al., "Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation", Medical hypotheses, vol. 175, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:493349. [Accessed: 05 May 2024]

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Metadata
Title (english)Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation
AuthorVedrana Drvar
AuthorDalen Legović
AuthorGordana Čanadi Jurešić
AuthorBožena Ćurko-Cofek
AuthorTatjana Kehler
AuthorAna-Marija Laškarin
AuthorEmilio Nemčić
AuthorGordana Laškarin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Osteoarthritis (OA) is a chronic joint disease caused by both mechanical damage and metabolic factors, which intertwine in their pathogenetic pathways. We hypothesise that the oxidised cholesterol derivative, 7-ketocholesterol (7-KCh), represents a danger signal in the synovia of patients with OA and promotes low-grade inflammation. The study would aim to elucidate the possible immune mechanisms initiated by 7-KCh that contribute to oxidative stress and inflammation in the synovia and synovial CD68+ cells, which are mostly macrophages. The polarisation of synovial CD68+ cells, their tissue distribution in relation to T and natural killer (NK) cells, and the influence of 7-KCh on the phenotype and intracellular cytokine and chemokine production in suspension is worth analysing. We envisage that this research would contribute to a better understanding of the biology of CD68+ macrophages influenced by 7-KCh and encourage the development of therapeutic approaches based on directing macrophage polarisation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical hypotheses
Numberingvol. 175, 111078
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2023.111078
URN:NBNurn:nbn:hr:184:493349
Online first2023-04-15
Document URLhttp://bib.irb.hr/1267046
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-04-21 07:34:57