prikaz prve stranice dokumenta Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells
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Scientific paper - Original scientific paper
Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells
Croatica Chemica Acta, 81 (2008), 1; 191-202. urn:nbn:hr:184:278207
Blagojević, Gordana; Mahmutefendić, Hana; Kučić, Natalia; Ilić Tomaš, Maja; Lučin, Pero

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Blagojević, G., Mahmutefendić, H., Kučić, N., Ilić Tomaš, M. & Lučin, P. (2008). Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells. Croatica Chemica Acta, 81. (1), 191-202. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:278207

Blagojević, Gordana, et al. "Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells." Croatica Chemica Acta, vol. 81, no. 1, 2008, pp. 191-202. https://urn.nsk.hr/urn:nbn:hr:184:278207

Blagojević, Gordana, Hana Mahmutefendić, Natalia Kučić, Maja Ilić Tomaš and Pero Lučin. "Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells." Croatica Chemica Acta 81, no. 1 (2008): 191-202. https://urn.nsk.hr/urn:nbn:hr:184:278207

Blagojević, G., et al. (2008) 'Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells', Croatica Chemica Acta, 81(1), pp. 191-202. Available at: https://urn.nsk.hr/urn:nbn:hr:184:278207 (Accessed 14 April 2025)

Blagojević G, Mahmutefendić H, Kučić N, Ilić Tomaš M, Lučin P. Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells. Croatica Chemica Acta [Internet]. 2008 [cited 2025 April 14];81(1):191-202. Available at: https://urn.nsk.hr/urn:nbn:hr:184:278207

G. Blagojević, H. Mahmutefendić, N. Kučić, M. Ilić Tomaš and P. Lučin, "Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells", Croatica Chemica Acta, vol. 81, no. 1, pp. 191-202, 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:278207. [Accessed: 14 April 2025]

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Metadata
Title (english)Endocytic Trafficking of Cholera Toxin in Balb 3T3 Cells
AuthorGordana Blagojević
AuthorHana Mahmutefendić
AuthorNatalia Kučić
MBZ: 239812
AuthorMaja Ilić Tomaš
AuthorPero Lučin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Abstract (english)
Endocytosis of the cholera toxin B subunit (CTxB) in various cell lines has shown diversity of entry paths of cell surface bound ligands. The aim of this study was to clarify internalisation mechanism and endosomal trafficking of CTxB in murine fibroblasts (Balb 3T3 cells) and human epithelial cells (HeLa). We have shown that CTxB enters Balb 3T3 cells mainly via cholesterol-dependent endocytic pathway(s), while in HeLa cells clathrin endocytosis plays a major role. Early endosomal acidic gradient is required for CTxB progression towards the Golgi in HeLa cells, whereas a majority of internalised CTxB bypasses early endosomes (EEA1+ compartments) in Balb 3T3 cells. The acidic gradient is also required for exit from the Golgi into the late endosomes and degradation of CTxB in Balb 3T3 cells. Thus, the CTxB trafficking may help in the understanding of non-clathrin endocytic mechanisms and the complexity of late endosomal compartments.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 81, no. 1, pp. 191-202
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:184:278207
Publication2008
Document URLhttps://hrcak.srce.hr/23447
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-04-21 06:58:55