prikaz prve stranice dokumenta Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
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Scientific paper - Original scientific paper
Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
International journal of molecular sciences, 22 (2021); 12211. urn:nbn:hr:184:339322
Janković, Tamara; Dolenec, Petra; Rajič Bumber, Jelena; Gržeta, Nika; Križ, Jasna; Župan, Gordana; Pilipović, Kristina

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Janković, T., Dolenec, P., Rajič Bumber, J., Gržeta, N., Križ, J., Župan, G. & Pilipović, K. (2021). Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. International journal of molecular sciences, 22.. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:339322

Janković, Tamara, et al. "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice." International journal of molecular sciences, vol. 22, 2021. https://urn.nsk.hr/urn:nbn:hr:184:339322

Janković, Tamara, Petra Dolenec, Jelena Rajič Bumber, Nika Gržeta, Jasna Križ, Gordana Župan and Kristina Pilipović. "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice." International journal of molecular sciences 22 (2021). https://urn.nsk.hr/urn:nbn:hr:184:339322

Janković, T., et al. (2021) 'Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice', International journal of molecular sciences, 22. Available at: https://urn.nsk.hr/urn:nbn:hr:184:339322 (Accessed 15 November 2024)

Janković T, Dolenec P, Rajič Bumber J, Gržeta N, Križ J, Župan G, and sur.. Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice. International journal of molecular sciences [Internet]. 2021 [cited 2024 November 15];22. Available at: https://urn.nsk.hr/urn:nbn:hr:184:339322

T. Janković, et al., "Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice", International journal of molecular sciences, vol. 22, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:339322. [Accessed: 15 November 2024]

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Metadata
Title (english)Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
Title (english)Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice
AuthorTamara Janković
AuthorPetra Dolenec
AuthorJelena Rajič Bumber
AuthorNika Gržeta
AuthorJasna Križ
AuthorGordana Župan
AuthorKristina Pilipović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Traumatic brain injury (TBI) is a disabling disorder and a major cause of death and disability in the world. Both single and repetitive traumas affect the brain acutely but can also lead to chronic neurodegenerative changes. Clinical studies have shown some dissimilarities in transactive response DNA binding protein 43 (TDP-43) expression patterns following single versus repetitive TBI. We explored the acute cortical post-traumatic changes of TDP-43 using the lateral fluid percussion injury (LFPI) model of single moderate TBI in adult male mice and investigated the association of TDP-43 with post-traumatic neuroinflammation and synaptic plasticity. In the ipsilateral cortices of animals following LFPI, we found changes in the cytoplasmic and nuclear levels of TDP-43 and the decreased expression of postsynaptic protein 95 within the first 3 d post-injury. Subacute pathological changes of TDP-43 in the hippocampi of animals following LFPI and in mice exposed to repetitive mild TBI (rmTBI) were studied. Changes in the hippocampal TDP-43 expression patterns at 14 d following different brain trauma procedures showed pathological alterations only after single moderate, but not following rmTBI. Hippocampal LFPI-induced TDP-43 pathology was not accompanied by the microglial reaction, contrary to the findings after rmTBI, suggesting that different types of brain trauma may cause diverse pathophysiological changes in the brain, specifically related to the TDP-43 protein as well as to the microglial reaction. Taken together, our findings may contribute to a better understanding of the pathophysiological events following brain trauma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational journal of molecular sciences
Numberingvol. 22, 12211
e-ISSN1422-0067
URN:NBNurn:nbn:hr:184:339322
Publication2021
Document URLhttp://bib.irb.hr/1156692
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-15 09:32:11