prikaz prve stranice dokumenta Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey
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Scientific paper - Original scientific paper
Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey
Blood, 140 (2022), 26; 2773-2787. https://doi.org/10.1182/blood.2022017257
Pagano, Livio; Salmanton-García, Jon; Marchesi, Francesco; Blennow, Ola; Gomes da Silva, Maria; Glenthøj, Andreas; van Doesum, Jaap; Bilgin, Yavuz M.; López-García, Alberto; Itri, Federico; Nunes Rodrigues, Raquel; Weinbergerová, Barbora; Farina, Francesca; Dragonetti, Giulia; Berg Venemyr, Caroline; van Praet, Jens; Jakšić, Ozren; Valković, Toni; Falces-Romero, Iker; Martín-Pérez, Sonia; Jiménez, Moraima; Dávila-Vals, Julio; Schönlein, Martin; Ammatuna, Emanuele; Meers, Stef; Delia, Mario; Stojanoski, Zlate; Nordlander, Anna; Lahmer, Tobias; Imre Pinczés, László; Buquicchio, Caterina; Piukovics, Klára; Ormazabal-Vélez, Irati; Fracchiolla, Nicola; Samarkos, Michail; Méndez, Gustavo-Adolfo; Hernández-Rivas, José-Ángel; Espigado, Ildefonso; Cernan, Martin; Petzer, Verena; Lamure, Sylvain; di Blasi, Roberta; Marques de Almedia, Joyce; Dargenio, Michelina; Biernat, Monika M.; Sciumè, Mariarita; de Ramón, Cristina; de Jonge, Nick; Batinić, Josip; Aujayeb, Avinash; Marchetti, Monia; Fouquet, Guillemette; Fernández, Noemí; Zambrotta, Giovanni; Sacchi, Maria Vittoria; Guidetti, Anna; Demirkan, Fatih; Prezioso, Lucia; Ráčil, Zdeněk; Nucci, Marcio; Mladenović, Miloš; Liévin, Raphaël; Hanáková, Michaela; Gräfe, Stefanie; Sili, Uluhan; Machado, Marina; Cattaneo, Chiara; Adžić-Vukičević, Tatjana; Verga, Luisa; Labrador, Jorge; Rahimli, Laman; Bonanni, Matteo; Passamonti, Francesco; Pagliuca, Antonio; Corradini, Paolo; Hoenigl, Martin; Koehler, Philipp; Busca, Alessandro; Cornely, Oliver A. More authors...

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Pagano, L., Salmanton García, J., Marchesi, F., Blennow, O., Gomes da Silva, M., Glenthøj, A. ... Cornely, O. A. (2022). Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey. Blood, 140. (26), 2773-2787. doi: 10.1182/blood.2022017257

Pagano, Livio, et al. "Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey." Blood, vol. 140, no. 26, 2022, pp. 2773-2787. https://doi.org/10.1182/blood.2022017257

Pagano, Livio, Jon Salmanton García, Francesco Marchesi, Ola Blennow, Maria Gomes da Silva, Andreas Glenthøj, Jaap van Doesum, et al. "Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey." Blood 140, no. 26 (2022): 2773-2787. https://doi.org/10.1182/blood.2022017257

Pagano, L., et al. (2022) 'Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey', Blood, 140(26), pp. 2773-2787. doi: 10.1182/blood.2022017257

Pagano L, Salmanton García J, Marchesi F, Blennow O, Gomes da Silva M, Glenthøj A, and sur.. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey. Blood [Internet]. 2022 December 29 [cited 2025 April 22];140(26):2773-2787. doi: 10.1182/blood.2022017257

L. Pagano, et al., "Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey", Blood, vol. 140, no. 26, pp. 2773-2787, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:118019. [Accessed: 22 April 2025]

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Metadata
Title (english)Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey
AuthorLivio Pagano
AuthorJon Salmanton-García
AuthorFrancesco Marchesi
AuthorOla Blennow
AuthorMaria Gomes da Silva
AuthorAndreas Glenthøj
AuthorJaap van Doesum
AuthorYavuz M. Bilgin
AuthorAlberto López-García
AuthorFederico Itri
AuthorRaquel Nunes Rodrigues
AuthorBarbora Weinbergerová
AuthorFrancesca Farina
AuthorGiulia Dragonetti
AuthorCaroline Berg Venemyr
AuthorJens van Praet
AuthorOzren Jakšić
AuthorToni Valković
AuthorIker Falces-Romero
AuthorSonia Martín-Pérez
AuthorMoraima Jiménez
AuthorJulio Dávila-Vals
AuthorMartin Schönlein
AuthorEmanuele Ammatuna
AuthorStef Meers
AuthorMario Delia
AuthorZlate Stojanoski
AuthorAnna Nordlander
AuthorTobias Lahmer
AuthorLászló Imre Pinczés
AuthorCaterina Buquicchio
AuthorKlára Piukovics
AuthorIrati Ormazabal-Vélez
AuthorNicola Fracchiolla
AuthorMichail Samarkos
AuthorGustavo-Adolfo Méndez
AuthorJosé-Ángel Hernández-Rivas
AuthorIldefonso Espigado
AuthorMartin Cernan
AuthorVerena Petzer
AuthorSylvain Lamure
AuthorRoberta di Blasi
AuthorJoyce Marques de Almedia
AuthorMichelina Dargenio
AuthorMonika M. Biernat
AuthorMariarita Sciumè
AuthorCristina de Ramón
AuthorNick de Jonge
AuthorJosip Batinić
AuthorAvinash Aujayeb
AuthorMonia Marchetti
AuthorGuillemette Fouquet
AuthorNoemí Fernández
AuthorGiovanni Zambrotta
AuthorMaria Vittoria Sacchi
AuthorAnna Guidetti
AuthorFatih Demirkan
AuthorLucia Prezioso
AuthorZdeněk Ráčil
AuthorMarcio Nucci
AuthorMiloš Mladenović
AuthorRaphaël Liévin
AuthorMichaela Hanáková
AuthorStefanie Gräfe
AuthorUluhan Sili
AuthorMarina Machado
AuthorChiara Cattaneo
AuthorTatjana Adžić-Vukičević
AuthorLuisa Verga
AuthorJorge Labrador
AuthorLaman Rahimli
AuthorMatteo Bonanni
AuthorFrancesco Passamonti
AuthorAntonio Pagliuca
AuthorPaolo Corradini
AuthorMartin Hoenigl
AuthorPhilipp Koehler
AuthorAlessandro Busca
AuthorOliver A. Cornely
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Abstract Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult patients with HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing in 753 cases (49%), the Omicron variant was prevalent (517,... More 68.7%). Most of the patients received ≤2 vaccine doses before COVID-19 (1419, 91%), mostly mRNA-based (1377, 89%). Overall, 906 patients (59%) received COVID-19-specific treatment. After 30-day follow-up from COVID-19 diagnosis, 143 patients (9%) died. The mortality rate in patients with the Omicron variant was 7.9%, comparable to other variants, with a significantly lower 30-day mortality rate than in the prevaccine era (31%). In the univariable analysis, older age (P < .001), active HM (P < .001), and severe and critical COVID-19 (P = .007 and P < .001, respectively) were associated with mortality. Conversely, patients receiving monoclonal antibodies, even for severe or critical COVID-19, had a lower mortality rate (P < .001). In the multivariable model, older age, active disease, critical COVID-19, and 2-3 comorbidities were correlated with a higher mortality, whereas monoclonal antibody administration, alone (P < .001) or combined with antivirals (P = .009), was protective. Although mortality is significantly lower than in the prevaccination era, breakthrough COVID-19 in HM is still associated with considerable mortality. Death rate was lower in patients who received monoclonal antibodies, alone or in combination with antivirals. Less
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleBlood
Numberingvol. 140, no. 26, pp. 2773-2787
p-ISSN0006-4971
e-ISSN1528-0020
DOIhttps://doi.org/10.1182/blood.2022017257
URN:NBNurn:nbn:hr:184:118019
Publication2022-12-29
Document URLhttps://ashpublications.org/blood/article/140/26/2773/486672/Breakthrough-COVID-19-in-vaccinated-patients-with
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-02-01 07:48:04
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