The role of metallothionein in breast cancer

Bilić-Knežević, Sara; Tokić, Mirisa; Gulić, Tamara; Avirović, Manuela; Grebić, Damir

doi:10.20471/LO.2022.50.02-03.16

Scientific paper - Review paper

The role of metallothionein in breast cancer

Libri Oncologici : Croatian Journal of Oncology, 50 (2022), 2-3; 103-108. https://doi.org/10.20471/LO.2022.50.02-03.16

Bilić-Knežević, Sara; Tokić, Mirisa; Gulić, Tamara; Avirović, Manuela; Grebić, Damir

Cite this document

APA 6th Edition

Bilić Knežević, S., Tokić, M., Gulić, T., Avirović, M. & Grebić, D. (2022). The role of metallothionein in breast cancer. Libri Oncologici : Croatian Journal of Oncology, 50. (2-3), 103-108. doi: 10.20471/LO.2022.50.02-03.16

MLA 8th Edition

Bilić Knežević, Sara, et al. "The role of metallothionein in breast cancer." Libri Oncologici : Croatian Journal of Oncology, vol. 50, no. 2-3, 2022, pp. 103-108. https://doi.org/10.20471/LO.2022.50.02-03.16

Chicago 17th Edition

Bilić Knežević, Sara, Mirisa Tokić, Tamara Gulić, Manuela Avirović and Damir Grebić. "The role of metallothionein in breast cancer." Libri Oncologici : Croatian Journal of Oncology 50, no. 2-3 (2022): 103-108. https://doi.org/10.20471/LO.2022.50.02-03.16

Harvard

Bilić Knežević, S., et al. (2022) 'The role of metallothionein in breast cancer', Libri Oncologici : Croatian Journal of Oncology, 50(2-3), pp. 103-108. doi: 10.20471/LO.2022.50.02-03.16

Vancouver

Bilić Knežević S, Tokić M, Gulić T, Avirović M, Grebić D. The role of metallothionein in breast cancer. Libri Oncologici : Croatian Journal of Oncology [Internet]. 2022 [cited 2024 May 08];50(2-3):103-108. doi: 10.20471/LO.2022.50.02-03.16

IEEE

S. Bilić Knežević, M. Tokić, T. Gulić, M. Avirović and D. Grebić, "The role of metallothionein in breast cancer", Libri Oncologici : Croatian Journal of Oncology, vol. 50, no. 2-3, pp. 103-108, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:119237. [Accessed: 08 May 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:119237

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Metadata

Title (english)	The role of metallothionein in breast cancer
Title (croatian)	Uloga metalotionina u karcinomu dojke
Author	Sara Bilić-Knežević
Author	Mirisa Tokić
Author	Tamara Gulić
Author	Manuela Avirović
Author	Damir Grebić
Author's institution	University of Rijeka Faculty of Medicine (Department of Physiology, Immunology and Pathophxsiology)
Author's institution	University of Rijeka Faculty of Medicine (Department of Surgery)
Author's institution	University of Rijeka Faculty of Medicine (Department of General Pathology and Pathological Anatomy)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Pathology
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Pathophysiology
Abstract (english)	Metallothioneins (MTs) are a family of small cysteine-rich proteins involved in many physiological and pathological processes. Genes that encode the four isoforms of metallothioneins (MT1-M4) are located on chromosome 16q13. Strucutures of these four isoforms allow metallothioneins their various biological functions. Many studies have shown that MT plays an important role in carcinogenesis, tumour growth, its progression from local to metastatic disease and may contribute to resistence to chemotherapy and radiotherapy. Due to the fact that breast cancer is one of the leading causes of death in women worldwide it is important to better understand the biology of breast cancer. So, findings of MT could evenutally help as a prognostic tool and could lead to a possible new specific anti-cancer treatment.
Abstract (croatian)	Metalotioneini su skupina proteina bogatih cisteinima koji su uključeni u mnoge fiziološke i patološke procese. Geni koji kodiraju četiri izoforme metalotioneina locirani su na lokusu 16q13. Strukture ovih četiriju izoformi omogućuju metalotioneinima njihove razne biološke funkcije. Mnoge su studije pokazale da metalnotionein ima važnu ulogu u karcinogenezi, rastu tumora, njegovoj progresiji od lokalne prema metastatskoj bolesti te je povezan sa razvojem rezistencije na kemoterapiju i radioterapiju. Rak dojke jedan je od vodećih uzroka smrti u svijetu i važno je bolje razumijeti ulogu metalotioneina u različitim podtipovima karcinoma dojke. Ovakvi podaci mogli bi pomoći kao prognostički alat i voditi pronalasku novog specifičnog liječenja karcinoma.
Keywords (english)
Keywords (croatian)
Language	english
Language	croatian
Publication type	Scientific paper - Review paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Libri Oncologici : Croatian Journal of Oncology
Numbering	vol. 50, no. 2-3, pp. 103-108
p-ISSN	0300-8142
e-ISSN	2584-3826
DOI	https://doi.org/10.20471/LO.2022.50.02-03.16
URN:NBN	urn:nbn:hr:184:119237
Publication	2022
Document URL	https://hrcak.srce.hr/288531
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2023-01-31 10:29:39