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Scientific paper - Original scientific paper
Hepatoregenerative Role of Bone Morphogenetic Protein-9
Medical science monitor, 17 (2011), 12; 33-35. urn:nbn:hr:184:402397
Šoša, Ivan; Cvijanović, Olga; Ćelić, Tanja; Cuculić, Dražen; Crnčević Orlić, Željka; Vukelić, Lucian; Zoričić Cvek, Sanja; Đudarić, Luka; Bosnar, Alan; Bobinac, Dragica

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Šoša, I., Cvijanović, O., Ćelić, T., Cuculić, D., Crnčević Orlić, Ž., Vukelić, L. ... Bobinac, D. (2011). Hepatoregenerative Role of Bone Morphogenetic Protein-9. Medical science monitor, 17. (12), 33-35. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:402397

Šoša, Ivan, et al. "Hepatoregenerative Role of Bone Morphogenetic Protein-9." Medical science monitor, vol. 17, no. 12, 2011, pp. 33-35. https://urn.nsk.hr/urn:nbn:hr:184:402397

Šoša, Ivan, Olga Cvijanović, Tanja Ćelić, Dražen Cuculić, Željka Crnčević Orlić, Lucian Vukelić, Sanja Zoričić Cvek, Luka Đudarić, Alan Bosnar and Dragica Bobinac. "Hepatoregenerative Role of Bone Morphogenetic Protein-9." Medical science monitor 17, no. 12 (2011): 33-35. https://urn.nsk.hr/urn:nbn:hr:184:402397

Šoša, I., et al. (2011) 'Hepatoregenerative Role of Bone Morphogenetic Protein-9', Medical science monitor, 17(12), pp. 33-35. Available at: https://urn.nsk.hr/urn:nbn:hr:184:402397 (Accessed 12 November 2024)

Šoša I, Cvijanović O, Ćelić T, Cuculić D, Crnčević Orlić Ž, Vukelić L, and sur.. Hepatoregenerative Role of Bone Morphogenetic Protein-9. Medical science monitor [Internet]. 2011 [cited 2024 November 12];17(12):33-35. Available at: https://urn.nsk.hr/urn:nbn:hr:184:402397

I. Šoša, et al., "Hepatoregenerative Role of Bone Morphogenetic Protein-9", Medical science monitor, vol. 17, no. 12, pp. 33-35, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:402397. [Accessed: 12 November 2024]

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Metadata
Title (english)Hepatoregenerative Role of Bone Morphogenetic Protein-9
AuthorIvan Šoša
AuthorOlga Cvijanović
AuthorTanja Ćelić
AuthorDražen Cuculić
AuthorŽeljka Crnčević Orlić
AuthorLucian Vukelić
AuthorSanja Zoričić Cvek
AuthorLuka Đudarić
AuthorAlan Bosnar
AuthorDragica Bobinac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Forensic Medicine and Criminalistics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) super-family of cytokines, which regulate cell growth and differentiation during embryogenesis. Apart of that, the hypoglycemic potential of BMP-9 is of great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice and regulates directional glucose metabolism in hepatocytes ; therefore it is proposed to be a candidate hepatic insulin-sensitizing substance (HISS). In liver fibrosis, due to the portocaval shunt, insulin bypasses the organ and the liver undergoes atrophy. Parenteral administration of insulin reverses atrophy by stimulating mitogenic activity of the hepatocytes. Because BMP-9 has a signaling pathway similar to other BMPs and insulin, it is to be expected that BMP-9 has a certain regenerative role in the liver. Also supporting the above-mentioned is evidence of BMP- 9 expression in Dissè's spaces and BMP-7’s mitogenic activity in mucosal cells. However, further studies are needed to confirm the possible regenerative role of BMP-9.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleMedical science monitor
Numberingvol. 17, no. 12, pp. 33-35
p-ISSN1234-1010
URN:NBNurn:nbn:hr:184:402397
Publication2011
ProjectNumber: 062-0000000-0073
Title (croatian): Sudsko-medicinske i toksikološke značajke samoubojstava u Republici Hrvatskoj
Title (english): Forensic and toxicological features of suicides in the Republic of Croatia
Leader: Alan Bosnar
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620226-0207
Title (croatian): Promjene koštanog metabolizma u bolestima bubrega i jetre
Title (english): Metabolic bone disease and related kidney and liver disorders
Leader: Dragica Bobinac
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620226-0208
Title (croatian): Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva
Title (english): Bone as a target in diabetes mellitus and inflamatory bowel disease
Leader: Željka Crnčević Orlić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/547595
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-11-17 12:39:23