prikaz prve stranice dokumenta Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats
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Scientific paper - Original scientific paper
Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats
Periodicum biologorum, 98 (1996), 1; 107-110. urn:nbn:hr:184:824101
Župan, Gordana; Eraković, Vesna; Mršić, Jasenka; Varljen, Jadranka; Simonić, Ante; Milin, Čedomila

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Župan, G., Eraković, V., Mršić, J., Varljen, J., Simonić, A. & Milin, Č. (1996). Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats. Periodicum biologorum, 98. (1), 107-110. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:824101

Župan, Gordana, et al. "Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats." Periodicum biologorum, vol. 98, no. 1, 1996, pp. 107-110. https://urn.nsk.hr/urn:nbn:hr:184:824101

Župan, Gordana, Vesna Eraković, Jasenka Mršić, Jadranka Varljen, Ante Simonić and Čedomila Milin. "Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats." Periodicum biologorum 98, no. 1 (1996): 107-110. https://urn.nsk.hr/urn:nbn:hr:184:824101

Župan, G., et al. (1996) 'Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats', Periodicum biologorum, 98(1), pp. 107-110. Available at: https://urn.nsk.hr/urn:nbn:hr:184:824101 (Accessed 20 March 2025)

Župan G, Eraković V, Mršić J, Varljen J, Simonić A, Milin Č. Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats. Periodicum biologorum [Internet]. 1996 [cited 2025 March 20];98(1):107-110. Available at: https://urn.nsk.hr/urn:nbn:hr:184:824101

G. Župan, V. Eraković, J. Mršić, J. Varljen, A. Simonić and Č. Milin, "Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats", Periodicum biologorum, vol. 98, no. 1, pp. 107-110, 1996. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:824101. [Accessed: 20 March 2025]

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Title (english)Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats
AuthorGordana Župan
AuthorVesna Eraković
AuthorJasenka Mršić
AuthorJadranka Varljen
AuthorAnte Simonić
AuthorČedomila Milin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Background and purpose: A number of investigations support the hypothesisthat a common denominator of hypoxic cellular damage in the brain is an increase in intracellular CA2+ concentration that causes degradation of membrane phospholipids and liberation of cerebral free fatty acids, particularly free arachidonic acid (FFA). The aim of our study was to examine the effects of the calcium channel blockers, nicardipine and amlodipine, on the level of the brain FAA in rats exposed to hypoxia. Material and methods: The study was carried out on Hannover-Wistar rats. The drugs tested had been injected 30 minutes prior to hypoxia exposure. Rats were decapitated 15 minutes after losing the righting reflex. The brains of all animals were taken out and were frozen in liquid nitrogen. FAA was quantified using gas chromatography method. Results: The results of our experiments show that an accumulation of the brain FAA occurs during the period of posthypoxic normoxic reoxygenation in hypoxia-exposed rats. The tested doses of nicardipine and amplodipine did not influence the increase in the brain FAA level in hypoxic rats. Conclusions: The inhibition of the CA2+ influx via L-type of voltage-sensitive calcium channels is not sufficient for the attenuation of the release of the brain FAA in hypoxic rats.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePeriodicum biologorum
Numberingvol. 98, no. 1, pp. 107-110
p-ISSN0031-5362
URN:NBNurn:nbn:hr:184:824101
Publication1996
Document URLhttp://bib.irb.hr/187140
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-11-17 09:12:45