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Scientific paper - Review paper
Trovanje paracetamolom u djece
Medicina Fluminensis : Medicina Fluminensis, 52. (2016), 4.; 460-466. https://doi.org/10.21860/medflum2016_4ver
Verbić, Arijan; Lah Tomulić, Kristina; Butorac Ahel, Ivona; Milardović, Ana

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Verbić, A., Lah Tomulić, K., Butorac Ahel, I. & Milardović, A. (2016). Trovanje paracetamolom u djece. Medicina Fluminensis : Medicina Fluminensis, 52.. (4.), 460-466. doi: 10.21860/medflum2016_4ver

Verbić, Arijan, et al. "Trovanje paracetamolom u djece." Medicina Fluminensis : Medicina Fluminensis, vol. 52., no. 4., 2016, pp. 460-466. https://doi.org/10.21860/medflum2016_4ver

Verbić, Arijan, Kristina Lah Tomulić, Ivona Butorac Ahel and Ana Milardović. "Trovanje paracetamolom u djece." Medicina Fluminensis : Medicina Fluminensis 52., no. 4. (2016): 460-466. https://doi.org/10.21860/medflum2016_4ver

Verbić, A., et al. (2016) 'Trovanje paracetamolom u djece', Medicina Fluminensis : Medicina Fluminensis, 52.(4.), pp. 460-466. doi: 10.21860/medflum2016_4ver

Verbić A, Lah Tomulić K, Butorac Ahel I, Milardović A. Trovanje paracetamolom u djece. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2016 December 01 [cited 2024 November 16];52.(4.):460-466. doi: 10.21860/medflum2016_4ver

A. Verbić, K. Lah Tomulić, I. Butorac Ahel and A. Milardović, "Trovanje paracetamolom u djece", Medicina Fluminensis : Medicina Fluminensis, vol. 52., no. 4., pp. 460-466, December 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:153709. [Accessed: 16 November 2024]

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Metadata
Title (croatian)Trovanje paracetamolom u djece
Title (english)Paracetamol poisoning in children
AuthorArijan Verbić
AuthorKristina Lah Tomulić
AuthorIvona Butorac Ahel
AuthorAna Milardović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
Paracetamol je najčešće korišteni antipiretik i analgetik u djece i dobro je znana njegova potencijalna hepatotoksičnost. Današnja široka upotreba dovela je do činjenice da je to lijek koji najčešće dovodi do namjernih i nenamjernih otrovanja, kao i jetrene toksičnosti. Iako se terapijsko i nenamjerno predoziranje događa tipično u djece, oštećenje jetre i smrt uslijed trovanja paracetamolom su ipak rijetki u odnosu na adultnu populaciju. Unatoč tome, paracetamol je trenutno najznačajniji i najčešće identificirani uzrok akutnog jetrenog zatajenja u djece. U tom svjetlu donosimo ovaj pregledni članak o dobro utvrđenim patofiziološkim mehanizmima jetrenog oštećenja i aktualnim konceptima dijagnostike i liječenja akutnog otrovanja paracetamolom, s posebnim osvrtom na acetilcistein kao temeljnu, sigurnu i efikasnu terapijsku opciju u liječenju djece i adolescenata.
Abstract (english)
Paracetamol is the most commonly used antipyretic and analgesic in children and the association between paracetamol and hepatotoxicity has been well established. With it's widespread use, it became one of the most common pharmaceuticals associated with both unintentional and intentional poisoning and toxicity. Although therapeutic and unintentional overdosage typically occurs in children, hepatic damage or death due to paracetamol poisoning appears to be rare compared to adults. Despite this fact, paracetamol is currently a major and the most common identifiable cause of acute liver failure in children. Therefore, we bring this review article on well established modes of pathophysiologycal mechanisms of liver damage, current diagnostic and treatment concepts of acute paracetamol poisoning, and special overview of acetylcystein as cornerstone of therapy with proven safety and eficacy in children.
Keywords (croatian)
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 52., no. 4., pp. 460-466
p-ISSN0025-7729
DOIhttps://doi.org/10.21860/medflum2016_4ver
URN:NBNurn:nbn:hr:184:153709
Publication2016-12-01
Document URLhttp://hrcak.srce.hr/168379
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-10 15:21:02