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doctoral thesis
ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA
2021. urn:nbn:hr:184:508427
Raljević, Damir
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Cite this document

Raljević, D. (2021). ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA (Doctoral thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:508427

Raljević, Damir. "ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA." Doctoral thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:508427

Raljević, Damir. "ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA." Doctoral thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:508427

Raljević, D. (2021). 'ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA', Doctoral thesis, University of Rijeka, Faculty of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:508427

Raljević D. ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA [Doctoral thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2021 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:184:508427

D. Raljević, "ULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA", Doctoral thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:184:508427

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Metadata
TitleULOGA POLIMORFIZAMA GENA ZA PROTEINSKI NOSAČ I RECEPTOR ZA VITAMIN D U INFARKTU MIOKARDA
Title (english)THE ROLE OF VITAMIN D BINDING PROTEIN AND VITAMIN D RECEPTOR GENE POLYMORPHISM IN MYOCARDIAL INFARCTION
AuthorDamir Raljević
MentorViktor Peršić (mentor)
MentorSandra Kraljević Pavelić (komentor)
Committee memberNada Starčević Čizmarević (predsjednik povjerenstva)
Committee memberRoberta Petlevski (član povjerenstva)
Committee memberTeodora Zaninović Jurjević (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2021, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Cilj istraživanja: Kardiovaskularne bolesti su vodeći uzrok smrti u svijetu. Koronarna je bolest uzrok gotovo 50 % smrti od kardiovaskularnih bolesti. Rastući je broj znanstvenih dokaza da je deficit vitamina D čimbenik rizika u koronarnoj bolesti. S obzirom na to da je proteinski nosač za vitamin D (VDBP) glavni nosač svih oblika vitamina D te da receptor za vitamin D (VDR) predstavlja glavni put kojim vitamin D ostvaruje svoju funkciju, polimorfizmi gena za VDBP i VDR potencijalno mogu utjecati na funkcionalnost VDBP-a i VDR-a te remetiti akivnost vitamina D. Međutim, podaci u literaturi o utjecaju VDBP i VDR polimorfizama na koronarnu bolest su proturječni. Cilj nam je prezentirati nove dokaze utjecaja dvaju VDBP polimorfizama (rs4588, rs7041) te triju VDR polimorfizama (rs2228570, rs1544410, rs731236) na koronarnu bolest u pacijenata nakon akutnog infarkta miokarda te pronaći moguću povezanost ovih polimorfizama sa serumskom razinom 25-hidroksi vitamina (OH) D. Ispitanici i metode: Ovo opažajno presječno istraživanje uključilo je 155 ispitanika s koronarnom bolesti nakon akutnog infarkta miokarda te 104 ispitanika kontrolne skupine bez koronarne bolesti. Ispitanici obiju grupa su bijelci europskog porijekla. Frekvencije alela VDBP polimorfizama (rs4588, rs7041) i VDR polimorfizama (rs2228570, rs1544410, rs731236) istraživane su putem RT-PCR-a. Serumska razina vitamina D izmjerena je metodom tekuće kromatografije udružene s mass spektrometrijom (LC-MS/MS). Rezultati: Pronađena je povezanost VDBP (rs4588) T/T genotipa s anteroseptalnim infarktom miokarda. Također, pronađena je povezanost VDR (rs1544410) T/T genotipa te VDR (rs731236) G/G genotipa s pacijentima s koronarnom bolesti nakon infarkta miokarda. Nije utvrđena povezanost VDR (rs2228570) polimorfizma kao ni VDBP (rs7041) polimorfizma s pacijentima nakon infarkta miokarda. Zaključak: Dobiveni rezultati govore u prilog povezanosti VDBP (rs4588) T/T genotipa s anteroseptalnim infarktom miokarda te VDR (rs1544410) T/T genotipa i VDR (rs731236) G/G genotipa s rizikom za infarkt miokarda kod pacijenata s koronarnom bolesti.
Abstract (english)
Objectives: Cardiovascular diseases (CVD) are the leading cause od death worldwide. Coronary artery diseases (CAD) causes almost half of death of CVD. There is a growing amount of evidence that links vitamin D deficiency with CAD. Vitamin D binding protein (VDBP) is the main Vitamin D carrier. Vitamin D manifests its biological function through his vitamin D receptor (VDR). VDBP and VDR gene polymorphism potentially affects VDBP and VDR functionality and with that affect the vitamin D activity. However, data in the literature on the influence of VDBP and VDR polymorphisms on CAD are contradictory. The objective of this study is to present new evidence of the role of two VDBP gene pholymorphisms (rs4588, rs7041), three VDR gene polymorphisms (rs2228570, rs1544410, rs731236) on CAD in patients after acute myocardial infarction and find the eventual assotiation between these polymorphisms with the 25 hidroxyvittamin D serum level. Patients and Methods: In this cross sectional study there was included 155 participants with CAD after acute myocardial infarction and 104 participants in the control group without CAD. Participants in both groups were Caucasian of European origin. The allele frequency of VDBP polymorphysms (rs4588, rs7041) and VDR polymorphisms (rs2228570, rs1544410, rs731236) are assessed by RT-PCR. The vitamin D serum level is measured with liquid chromatography tandem mess spectrometry metode (LC-MS/MS) Results: the results show an assocition between VDBP (rs4588) T/T genotype and anteroseptal myocardial infarction. Also, the results show an association between VDR (rs1544410) T/T genotype and VDR (rs731236) G/G genotype and CAD in patients after acute myocardial infarction. There was no association between VDBP (rs7041) and VDR (rs2228570) polymorphism and CAD Conclusion: These results suggest that VDBP (rs4588) T/T genotype is an susceptibility factor for anterospetal myocardial factor. Alsto, that (rs1544410) T/T genotype and VDR (rs731236) G/G genotype is an susceptibility factor for CAD in patients after acute myocardial infarction.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:508427
Promotion2022
Study programmeTitle: Biomedicine Postgraduate (doctoral) study programme
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2022-08-04 08:10:20