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Scientific paper - Original scientific paper
SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes
Viruses, 14 (2022), 6; 1292. https://doi.org/10.3390/v14061292
Ynga-Durand, Mario; Maaß, Henrike; Milošević, Marko; Krstanović, Fran; Pribanić Matešić, Marina; Jonjić, Stipan; Protić, Alen; Brizić, Ilija; Šustić, Alan; Čičin-Šain, Luka

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Ynga Durand, M., Maaß, H., Milošević, M., Krstanović, F., Pribanić Matešić, M., Jonjić, S. ... Čičin Šain, L. (2022). SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Viruses, 14. (6). doi: 10.3390/v14061292

Ynga Durand, Mario, et al. "SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes." Viruses, vol. 14, no. 6, 2022. https://doi.org/10.3390/v14061292

Ynga Durand, Mario, Henrike Maaß, Marko Milošević, Fran Krstanović, Marina Pribanić Matešić, Stipan Jonjić, Alen Protić, Ilija Brizić, Alan Šustić and Luka Čičin Šain. "SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes." Viruses 14, no. 6 (2022). https://doi.org/10.3390/v14061292

Ynga Durand, M., et al. (2022) 'SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes', Viruses, 14(6). doi: 10.3390/v14061292

Ynga Durand M, Maaß H, Milošević M, Krstanović F, Pribanić Matešić M, Jonjić S, and sur.. SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Viruses [Internet]. 2022 June 14 [cited 2024 December 05];14(6). doi: 10.3390/v14061292

M. Ynga Durand, et al., "SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes", Viruses, vol. 14, no. 6, June 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:689251. [Accessed: 05 December 2024]

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Metadata
Title (english)SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes
AuthorMario Ynga-Durand
AuthorHenrike Maaß
AuthorMarko Milošević
AuthorFran Krstanović
AuthorMarina Pribanić Matešić
AuthorStipan Jonjić
AuthorAlen Protić
AuthorIlija Brizić
AuthorAlan Šustić
AuthorLuka Čičin-Šain
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Intensive Care
Abstract (english)
While SARS-CoV-2 detection in sputum and swabs from the upper respiratory tract has been used as a diagnostic tool, virus quantification showed poor correlation to disease outcome and thus, poor prognostic value. Although the pulmonary compartment represents a relevant site for viral load analysis, limited data exploring the lower respiratory tract is available, and its association to clinical outcomes is relatively unknown. Using bronchoalveolar lavage (BAL) and serum samples, we quantified SARS-CoV-2 copy numbers in the pulmonary and systemic compartments of critically ill patients admitted to the intensive care unit of a COVID-19 referral hospital in Croatia during the second and third pandemic waves. Clinical data, including 30-day survival after ICU admission, were included. We found that elevated SARS-CoV-2 copy numbers in both BAL and serum samples were associated with fatal outcomes. Remarkably, the highest and earliest viral loads after initiation of mechanical ventilation support were increased in the non-survival group. Our results imply that viral loads in the lungs contribute to COVID-19 disease severity, while blood titers correlate with lung virus titers, albeit at a lower level. Moreover, they suggest that BAL SARS-CoV-2 copy number quantification at ICU admission may provide a predictive parameter of clinical COVID-19 outcomes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleViruses
Numberingvol. 14, no. 6, 1292
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v14061292
URN:NBNurn:nbn:hr:184:689251
Publication2022-06-14
ProjectNumber: IP-CORONA-2020-04-2073
Title (croatian): Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2
Title (english): No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom
Acronym: CoV2mAbs
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: IP-CORONA
Document URLhttps://www.mdpi.com/1999-4915/14/6/1292
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-07-06 06:54:13