Introduction: Proximal pancreatectomy is an operation to remove tumor and non-tumor pathology of the head of the Pancreas, the distal Choledochus, the papilla of Vater, the ampulla of Vater and the duodenum. Distal pancreatectomy is an operation to remove tumor and non-tumor pathology of the body and the tail of the pancreas and the spleen. The purpose of this retrospective research is to analyze: types of pancreatectomy in relation to the cause (tumor and non-tumor diagnoses), age and sex of patients, localization and histological characteristics of diagnosed tumors and to analyze clinical and pathological characteristics of pancreatic ductal adenocarcinoma. Subjects and methods: This retrospective research includes patients treated with proximal or distal pancreatectomy between 2015 and 2021. The research includes 115 patients from Clinical Hospital Center Rijeka database. Results: In 115 operations over 7 years 87 % were caused by tumor, while 13 % were caused by non-tumor pathology. Proximal pancreatectomy was performed more often than distal (78 %), mostly in men 60 to 79 years old with diagnosis of PDAC localized in the head of the pancreas. They are followed by tumors of the papilla of Vater, the adenocarcinomas of the distal Choledochus, the ampulla of Vater and the duodenum. After distal pancreatectomy, all diagnosed tumors are localized in the body and the tail of the pancreas and mostly are PDAC's. Pancreatic ductal adenocarcinoma (46 % of all tumors) most commonly occur in the head of the pancreas, in men, average age 68 years, average tumor size 3.35 cm, grade GIII, with positive perineural and lymphovascular invasion, and at stage IIB. Conclusion: Proximal pancreatectomy is a more frequent procedure than distal due to the frequency of pathology involving the head of the pancreas and surrounding structures - most often pancreatic ductal adenocarcinoma.