Objectives: To determine the frequency and characteristics of non-melanoma skin cancers of the maxillofacial region. Patients and methods: The retrospective study was conducted, with an insight into the IBIS system, on a clinical sample of patients, over the age of 18 who were treated at the Clinic for Maxillofacial Surgery of the Clinical Hospital Centre Rijeka, in the period from January 1, 2021. to December 31, 2021. From the pathohistological diagnoses, basic data of patients (such as age, sex and date of birth) and data of the analyzed cancers (such as size, location, type, subtype etc.) were recorded and statistically processed. The results obtained were compared with similar studies in the world and the Republic of Croatia. Results: In the analyzed group of patients, it was found that men and women alike suffer from non-melanoma skin cancers (51% : 49%, in favor of men). The most common diagnosis is basal cell carcinoma, which accounts for 2/3 of all cases, while a smaller part is the diagnosis of squamous cell and other cancers (such as adnexal carcinomas). The incidence of these diagnoses begins to increase between 50 and 60 years of age, regardless of gender and there is no statistically significant difference in the incidence of each type of cancer depending on gender. The group of patients dignosed with SCC is older than the group diagnosed with BCC (by average of 5.2 years). BCC occurs more frequently on the nose (25% of cases) with a predominance of aggressive subtypes (infiltrative variant), while SCC (in situ variant) occurs more frequently on the cheek (25%) compared to other anatomical subunits of the head and neck. There was statistically significant difference in the incidence of cancer at certain anatomical sites according to gender (p= 0.022), so men have a higher incidence of tumours on the neck, ear and cheek compared to women. Conclusions: NMSC are equally common in men and women. A diagnosis of BCC is more common than a diagnosis of SCC. Basaliomas are more common on the nose and spinaliomas on the cheeks. Men have a higher incidence of cancer of the neck, ear and cheek than women.