prikaz prve stranice dokumenta Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60
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Scientific paper - Original scientific paper
Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60
Molecular immunology, 47 (2009), 1; 114-122. https://doi.org/10.1016/j.molimm.2009.02.010
Arapović, Jurica; Lenac Roviš, Tihana; Reddy, A.B.; Krmpotić, Astrid; Jonjić, Stipan

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Arapović, J., Lenac Roviš, T., Reddy, A., Krmpotić, A. & Jonjić, S. (2009). Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Molecular immunology, 47. (1), 114-122. doi: 10.1016/j.molimm.2009.02.010

Arapović, Jurica, et al. "Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60." Molecular immunology, vol. 47, no. 1, 2009, pp. 114-122. https://doi.org/10.1016/j.molimm.2009.02.010

Arapović, Jurica, Tihana Lenac Roviš, A.B. Reddy, Astrid Krmpotić and Stipan Jonjić. "Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60." Molecular immunology 47, no. 1 (2009): 114-122. https://doi.org/10.1016/j.molimm.2009.02.010

Arapović, J., et al. (2009) 'Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60', Molecular immunology, 47(1), pp. 114-122. doi: 10.1016/j.molimm.2009.02.010

Arapović J, Lenac Roviš T, Reddy A, Krmpotić A, Jonjić S. Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Molecular immunology [Internet]. 2009 [cited 2024 December 05];47(1):114-122. doi: 10.1016/j.molimm.2009.02.010

J. Arapović, T. Lenac Roviš, A. Reddy, A. Krmpotić and S. Jonjić, "Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60", Molecular immunology, vol. 47, no. 1, pp. 114-122, 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:193906. [Accessed: 05 December 2024]

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Metadata
Title (english)Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60
AuthorJurica Arapović
AuthorTihana Lenac Roviš
AuthorA.B. Reddy
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Both human and mouse cytomegalovirus (CMV) encode proteins that inhibit the activation of NK cells by down-regulating the cellular ligands for activating NK cell receptor, NKG2D. MCMV proteins m145, m152 and m155 interfere with the expression of all known NKG2D ligands, MULT-1, RAE-1 family members and H60, respectively, whereas m138 affects the expression of MULT-1 and H60. Here we show that m152 affects the maturation of newly synthesized RAE-1 molecules, but is not sufficient to prevent surface expression of RAE-1varepsilon. We have identified m138 as a main inhibitor of the surface expression of RAE-1varepsilon. In contrast to m152, m138 affects the surface-resident protein leading to its endocytosis, which can be prevented by a dynamin inhibitor. Moreover, we demonstrated that m138 does not need other viral proteins to down-modulate the expression of RAE-1varepsilon.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMolecular immunology
Numberingvol. 47, no. 1, pp. 114-122
p-ISSN0161-5890
DOIhttps://doi.org/10.1016/j.molimm.2009.02.010
URN:NBNurn:nbn:hr:184:193906
Publication2009
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Title (english): Molecular mechanisms of immune evasion by cytomegalovirus
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621261-1268
Title (croatian): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Title (english): The role of cytomegalovirus immunoevasion genes in latency
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/442663
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-24 14:57:53