prikaz prve stranice dokumenta Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)
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Scientific paper - Original scientific paper
Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)
Oncology Letters, 15 (2017), 1; 2335-2339. https://doi.org/10.3892/ol.2017.7576
Bačić, Ivan; Karlo, Robert; Zadro, Ana; Zadro, Zvonko; Skitarelić, Neven; Antabak, Anko

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Bačić, I., Karlo, R., Zadro, A., Zadro, Z., Skitarelić, N. & Antabak, A. (2017). Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA). Oncology Letters, 15. (1), 2335-2339. doi: 10.3892/ol.2017.7576

Bačić, Ivan, et al. "Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)." Oncology Letters, vol. 15, no. 1, 2017, pp. 2335-2339. https://doi.org/10.3892/ol.2017.7576

Bačić, Ivan, Robert Karlo, Ana Zadro, Zvonko Zadro, Neven Skitarelić and Anko Antabak. "Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)." Oncology Letters 15, no. 1 (2017): 2335-2339. https://doi.org/10.3892/ol.2017.7576

Bačić, I., et al. (2017) 'Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)', Oncology Letters, 15(1), pp. 2335-2339. doi: 10.3892/ol.2017.7576

Bačić I, Karlo R, Zadro A, Zadro Z, Skitarelić N, Antabak A. Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA). Oncology Letters [Internet]. 2017 [cited 2024 December 02];15(1):2335-2339. doi: 10.3892/ol.2017.7576

I. Bačić, R. Karlo, A. Zadro, Z. Zadro, N. Skitarelić and A. Antabak, "Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)", Oncology Letters, vol. 15, no. 1, pp. 2335-2339, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:176128. [Accessed: 02 December 2024]

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Metadata
Title (english)Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)
AuthorIvan Bačić
MBZ: 247866
AuthorRobert Karlo
MBZ: 287321
AuthorAna Zadro
AuthorZvonko Zadro
MBZ: 216645
AuthorNeven Skitarelić
AuthorAnko Antabak
MBZ: 217751
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Otorhinolaryngology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of the present study was to evaluate angiogenesis by determining the micro vascular density (MVD) and the expression of vascular endothelial growth factor (VEGF-A) in advanced non-small cell lung cancer (NSCLC) tumor samples, and to analyze their associations with clinical parameters and survival. Tumor tissue specimens of fifty patients (41 males and 9 females), who underwent radical surgical treatment for NSCLC in stage IIIA (T1-3N2) were collected for immunohistochemical analysis. MVD evaluation was performed using an anti-CD31 monoclonal antibody and VEGF-A expression using a polyclonal anti-VEGF-A antibody. The results were associated with two-year survival. Statistical analysis revealed significant associations in the level of angiogenesis (high MVD) and shorter survival of patients with NSCLC (P=0.0007). VEGF-A expression showed no association with micro vascular density (P=0.51) or survival (P=0.68). There was no significant association between MVD and VEGF-A. The measurable, clinical MVD parameters could be used as a reliable prognostic factor for the survival of patients with advanced NSCLC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleOncology Letters
Numberingvol. 15, no. 1, pp. 2335-2339
p-ISSN1792-1074
DOIhttps://doi.org/10.3892/ol.2017.7576
URN:NBNurn:nbn:hr:184:176128
Publication2017
Document URLhttp://bib.irb.hr/956926
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-14 11:22:13