prikaz prve stranice dokumenta The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
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Scientific paper - Original scientific paper
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
Nature Immunology, 20 (2019); 1012-1022. https://doi.org/10.1038/s41590-019-0417-y
Mattiola, Irene; Tomay, Federica; De Pizzol, Maria; Silva-Gomes, Rita; Savino, Benedetta; Gulić, Tamara; Doni, Andrea; Lonardi, Silvia; Boutet, Marie Astrid; Nerviani, Alessandra; Carriero, Roberta; Molgora, Martina; Stravalaci, Matteo; Morone, Diego; Shalova, Irina N.; Lee, Yunquin; Biswas, Subhra K.; Mantovani, Giovanna; Sironi, Marina; Pitzalis, Costantino; Vermi, William; Bottazzi, Barbara; Mantovani, Alberto; Locati, Massimo More authors...

Cite this document

Mattiola, I., Tomay, F., De Pizzol, M., Silva Gomes, R., Savino, B., Gulić, T. ... Locati, M. (2019). The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature Immunology, 20., 1012-1022. doi: 10.1038/s41590-019-0417-y

Mattiola, Irene, et al. "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis." Nature Immunology, vol. 20, 2019, pp. 1012-1022. https://doi.org/10.1038/s41590-019-0417-y

Mattiola, Irene, Federica Tomay, Maria De Pizzol, Rita Silva Gomes, Benedetta Savino, Tamara Gulić, Andrea Doni, et al. "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis." Nature Immunology 20 (2019): 1012-1022. https://doi.org/10.1038/s41590-019-0417-y

Mattiola, I., et al. (2019) 'The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis', Nature Immunology, 20, pp. 1012-1022. doi: 10.1038/s41590-019-0417-y

Mattiola I, Tomay F, De Pizzol M, Silva Gomes R, Savino B, Gulić T, and sur.. The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature Immunology [Internet]. 2019 [cited 2025 February 27];20:1012-1022. doi: 10.1038/s41590-019-0417-y

I. Mattiola, et al., "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis", Nature Immunology, vol. 20, pp. 1012-1022, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:537822. [Accessed: 27 February 2025]

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Metadata
Title (english)The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
AuthorIrene Mattiola
AuthorFederica Tomay
AuthorMaria De Pizzol
AuthorRita Silva-Gomes
AuthorBenedetta Savino
AuthorTamara Gulić
AuthorAndrea Doni
AuthorSilvia Lonardi
AuthorMarie Astrid Boutet
AuthorAlessandra Nerviani
AuthorRoberta Carriero
AuthorMartina Molgora
AuthorMatteo Stravalaci
AuthorDiego Morone
AuthorIrina N. Shalova
AuthorYunquin Lee
AuthorSubhra K. Biswas
AuthorGiovanna Mantovani
AuthorMarina Sironi
AuthorCostantino Pitzalis
AuthorWilliam Vermi
AuthorBarbara Bottazzi
AuthorAlberto Mantovani
AuthorMassimo Locati
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell–mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell–mediated resistance to metastasis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Immunology
Numberingvol. 20, pp. 1012-1022
p-ISSN1529-2908
e-ISSN1529-2916
DOIhttps://doi.org/10.1038/s41590-019-0417-y
URN:NBNurn:nbn:hr:184:537822
Publication2019
Document URLhttp://bib.irb.hr/1050153
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-11 17:17:56