prikaz prve stranice dokumenta The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma
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Scientific paper - Original scientific paper
The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma
Pathology, research and practice, 212 (2016), 6; 509-516. https://doi.org/10.1016/j.prp.2015.11.021
Babarović, Emina; Valković, Toni; Budisavljević, Ivana; Balen, Iva; Štifter, Sanja; Duletić-Načinović, Antica; Lučin, Ksenija; Jonjić, Nives

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Babarović, E., Valković, T., Budisavljević, I., Balen, I., Štifter, S., Duletić Načinović, A. ... Jonjić, N. (2016). The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology, research and practice, 212. (6), 509-516. doi: 10.1016/j.prp.2015.11.021

Babarović, Emina, et al. "The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology, research and practice, vol. 212, no. 6, 2016, pp. 509-516. https://doi.org/10.1016/j.prp.2015.11.021

Babarović, Emina, Toni Valković, Ivana Budisavljević, Iva Balen, Sanja Štifter, Antica Duletić Načinović, Ksenija Lučin and Nives Jonjić. "The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma." Pathology, research and practice 212, no. 6 (2016): 509-516. https://doi.org/10.1016/j.prp.2015.11.021

Babarović, E., et al. (2016) 'The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma', Pathology, research and practice, 212(6), pp. 509-516. doi: 10.1016/j.prp.2015.11.021

Babarović E, Valković T, Budisavljević I, Balen I, Štifter S, Duletić Načinović A, and sur.. The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma. Pathology, research and practice [Internet]. 2016 [cited 2024 December 05];212(6):509-516. doi: 10.1016/j.prp.2015.11.021

E. Babarović, et al., "The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma", Pathology, research and practice, vol. 212, no. 6, pp. 509-516, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:347840. [Accessed: 05 December 2024]

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Title (english)The expression of osteopontin and vascular endothelial growth factor in correlation with angiogenesis in monoclonal gammopathy of undetermined significance and multiple myeloma
AuthorEmina Babarović
AuthorToni Valković
AuthorIvana Budisavljević
AuthorIva Balen
AuthorSanja Štifter
AuthorAntica Duletić-Načinović
AuthorKsenija Lučin
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Several studies have shown a gradual increase in the extent of bone marrow angiogenesis in various stages of proliferative plasma cell disorders, from monoclonal gammopathy of undetermined significance (MGUS) to active multiple myeloma (MM). The main aim of this study was to evaluate tumor angiogenesis parameters in detail and to correlate them with the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF) in the bone marrow of patients with MGUS and MM. In addition, we wanted to determine their prognostic significance in active MM. Ninety- five patients were enrolled in the study: 14 diagnosed with MGUS, 13 with asymptomatic myeloma (AMM) and 68 with active MM. Computer assisted image analysis was used to determine the angiogenesis parameters, the quantity of microvessels per 1mm2 (MVD), the area occupied by microvessels per 1mm2 and the percentage of microvessel area in total section area (TVA). Double immunohistochemical methods CD138+VEGF and CD138+OPN were used to evaluate expression of these proteins in plasma cells, and OPN was also analyzed for its interstitial expression (iOPN). A significant positive correlation was determined between VEGF and iOPN with angiogenic parameters in the MGUS stage of the disease. In advanced stages of the disease, a significant negative correlation was recorded between OPN and iOPN with parameters of angiogenesis. Overall survival was significantly shorter for patients with negative iOPN (p=0.002) and higher angiogenic parameters, MVD (p=0.009), TVA (p=0.008) and area of microvessels per 1mm2 (p=0.02). Positive VEGF expression in our model predicted a better three-year survival of patients with active MM (OR: 5.25, p=0.03 ; HR: 0.44, p=0.04). The results of our study suggested a possible key role of VEGF and OPN in the induction of angiogenesis in early-stage disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathology, research and practice
Numberingvol. 212, no. 6, pp. 509-516
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2015.11.021
URN:NBNurn:nbn:hr:184:347840
Publication2016
Document URLhttp://bib.irb.hr/812276
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-03-10 18:06:28