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Scientific paper - Original scientific paper
Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.
Cellular physiology and biochemistry, 42 (2017), 6; 2318-2329. https://doi.org/10.1159/000480004
Šućurović, Sandra; Nikolić, Tamara; Brosens, J. Jan; Mulac-Jeričević, Biserka

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Šućurović, S., Nikolić, T., Brosens, J. J. & Mulac Jeričević, B. (2017). Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.. Cellular physiology and biochemistry, 42. (6), 2318-2329. doi: 10.1159/000480004

Šućurović, Sandra, et al. "Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.." Cellular physiology and biochemistry, vol. 42, no. 6, 2017, pp. 2318-2329. https://doi.org/10.1159/000480004

Šućurović, Sandra, Tamara Nikolić, J. Jan Brosens and Biserka Mulac Jeričević. "Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.." Cellular physiology and biochemistry 42, no. 6 (2017): 2318-2329. https://doi.org/10.1159/000480004

Šućurović, S., et al. (2017) 'Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.', Cellular physiology and biochemistry, 42(6), pp. 2318-2329. doi: 10.1159/000480004

Šućurović S, Nikolić T, Brosens JJ, Mulac Jeričević B. Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.. Cellular physiology and biochemistry [Internet]. 2017 [cited 2025 April 02];42(6):2318-2329. doi: 10.1159/000480004

S. Šućurović, T. Nikolić, J. J. Brosens and B. Mulac Jeričević, "Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.", Cellular physiology and biochemistry, vol. 42, no. 6, pp. 2318-2329, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:416742. [Accessed: 02 April 2025]

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Metadata
Title (english)Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.
AuthorSandra Šućurović
AuthorTamara Nikolić
AuthorJ. Jan Brosens
AuthorBiserka Mulac-Jeričević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Abstract (english)
BACKGROUND: Fibroblast growth factors (FGFs), in complex with their receptors (FGFRs), regulate a broad spectrum of biological functions including cellular proliferation, survival, migration, and differentiation. In human endometrial stromal cells, FGF9 is regulated with estrogen (E). METHODS/RESULTS: First, we report that in uterus tissue of ovariectomized wild type mice, FGF9 is present in three isoforms and is regulated with E. Second, we found that during peri-implantation, Fgf9 expression reached its peak at day 4.5 of pregnancy. Immunofluorescence analyses demonstrated overlapping FGF9 and COX2 expression surrounding the blastocyst attachment site. Next, we identified FGF9- and CD31-positive cells as a part of the microvessels ; however, expression was localized to a distinct population of cells. Finally, our data showed synchronized, spatial expression of FGF9 on the luminal epithelium with FGFR2 present on the trophectoderm. CONCLUSION: Our data suggest that FGF9 is a crucial factor required to establish the appropriate microenvironment for successful implantation and the maintenance of pregnancy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCellular physiology and biochemistry
Numberingvol. 42, no. 6, pp. 2318-2329
p-ISSN1015-8987
DOIhttps://doi.org/10.1159/000480004
URN:NBNurn:nbn:hr:184:416742
Publication2017
ProjectNumber: 13.06.1.1.08
Title (croatian): Uloga progesterona u reproduktivnim i nereproduktivnim organima
Leader: Biserka Mulac-Jeričević
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/957688
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-09 11:37:37