prikaz prve stranice dokumenta Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications
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Scientific paper - Original scientific paper
Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications
Clinical rheumatology, 35 (2016), 10; 2565-2571. https://doi.org/10.1007/s10067-016-3377-8
Čulić, Ognjen; Cordero, Mario D.; Žanić- Grubišić, Tihana; Somborac-Bačura, Anita; Batičić Pučar, Lara; Detel, Dijana; Varljen, Jadranka; Barišić, Karmela

Cite this document

Čulić, O., Cordero, M. D., Žanić Grubišić, T., Somborac Bačura, A., Batičić Pučar, L., Detel, D. ... Barišić, K. (2016). Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications. Clinical rheumatology, 35. (10), 2565-2571. doi: 10.1007/s10067-016-3377-8

Čulić, Ognjen, et al. "Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications." Clinical rheumatology, vol. 35, no. 10, 2016, pp. 2565-2571. https://doi.org/10.1007/s10067-016-3377-8

Čulić, Ognjen, Mario D. Cordero, Tihana Žanić Grubišić, Anita Somborac Bačura, Lara Batičić Pučar, Dijana Detel, Jadranka Varljen and Karmela Barišić. "Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications." Clinical rheumatology 35, no. 10 (2016): 2565-2571. https://doi.org/10.1007/s10067-016-3377-8

Čulić, O., et al. (2016) 'Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications', Clinical rheumatology, 35(10), pp. 2565-2571. doi: 10.1007/s10067-016-3377-8

Čulić O, Cordero MD, Žanić Grubišić T, Somborac Bačura A, Batičić Pučar L, Detel D, and sur.. Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications. Clinical rheumatology [Internet]. 2016 [cited 2025 January 20];35(10):2565-2571. doi: 10.1007/s10067-016-3377-8

O. Čulić, et al., "Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications", Clinical rheumatology, vol. 35, no. 10, pp. 2565-2571, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:388913. [Accessed: 20 January 2025]

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Metadata
Title (english)Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications
AuthorOgnjen Čulić
MBZ: 137063
AuthorMario D. Cordero
AuthorTihana Žanić- Grubišić
MBZ: 80883
AuthorAnita Somborac-Bačura
MBZ: 298345
AuthorLara Batičić Pučar
AuthorDijana Detel
AuthorJadranka Varljen
AuthorKarmela Barišić
MBZ: 187331
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Fibromyalgia (FM) is a chronic pain syndrome with number of symptoms that present challenge in terms of diagnosis and treatment. Patients with FM show abnormal profile of purines in plasma. In this work, we measured serum activities of enzymes involved in purine metabolism, namely total adenosine deaminase (ADE) and its isoforms (ADE1 and ADE2), ecto- ATPase, and 5′- nucleotidase (5′-NT). We also measured activity of dipeptidyl peptidase IV (DPPIV) and prolyl endopeptidase (PEP). Spectrophotometric and fluorometric methods were used for enzyme activity determinations. Enzyme activities were measured in sera of 24 patients with FM that were not undergoing pharmacological treatment during the study. Control group comprised 32 healthy control subjects. Significantly higher activities of total ADE (P = 0.025) and ADE2 (P = 0.011) were observed in FM patients, while no significant differences in ADE1, ecto-ATPase, and 5′-NT activities (P > 0.05) were found when compared to healthy controls. Moreover, increase in the activity of DPPIV (P = 0.015) and lower activity of PEP (P = 0.011) were also found in the FM group. ROC analysis pointed to different diagnostic sensitivities/specificities for individual enzyme activities measured as follows: ADE (50.0/87.5), ADE2 (41.7/90.6), DPPIV (62.5/71.9), and PEP (83.3/62.5). ADE2 and PEP were shown to be independent predictors of FM, while combination of the two gives AUC of 0.786 (95 % confidence interval of 0.656–0.885, P < 0.05). Our results are showing that serum activities of ADE2 and PEP could be useful as biomarkers for FM diagnosis. However, relatively low diagnostic sensitivity of ADE2 and specificity of PEP must be taken into account.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical rheumatology
Numberingvol. 35, no. 10, pp. 2565-2571
p-ISSN0770-3198
DOIhttps://doi.org/10.1007/s10067-016-3377-8
URN:NBNurn:nbn:hr:184:388913
Publication2016
Document URLhttp://bib.irb.hr/836837
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-08 14:47:03