prikaz prve stranice dokumenta Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications
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Scientific paper - Original scientific paper
Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13 (2019); 496-499. https://doi.org/10.1016/j.dsx.2018.11.001
Bulum, Tomislav; Vučić Lovrenčić, Marijana; Tomić, Martina; Vučković Rebrina, Sandra; Roso, Vinko; Kolarić, Branko; Vuksan, Vladimir; Duvnjak, Lea

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Bulum, T., Vučić Lovrenčić, M., Tomić, M., Vučković Rebrina, S., Roso, V., Kolarić, B. ... Duvnjak, L. (2019). Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13., 496-499. doi: 10.1016/j.dsx.2018.11.001

Bulum, Tomislav, et al. "Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications." Diabetes & Metabolic Syndrome: Clinical Research & Reviews, vol. 13, 2019, pp. 496-499. https://doi.org/10.1016/j.dsx.2018.11.001

Bulum, Tomislav, Marijana Vučić Lovrenčić, Martina Tomić, Sandra Vučković Rebrina, Vinko Roso, Branko Kolarić, Vladimir Vuksan and Lea Duvnjak. "Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications." Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13 (2019): 496-499. https://doi.org/10.1016/j.dsx.2018.11.001

Bulum, T., et al. (2019) 'Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications', Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13, pp. 496-499. doi: 10.1016/j.dsx.2018.11.001

Bulum T, Vučić Lovrenčić M, Tomić M, Vučković Rebrina S, Roso V, Kolarić B, and sur.. Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 2019 [cited 2024 November 21];13:496-499. doi: 10.1016/j.dsx.2018.11.001

T. Bulum, et al., "Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications", Diabetes & Metabolic Syndrome: Clinical Research & Reviews, vol. 13, pp. 496-499, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:672554. [Accessed: 21 November 2024]

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Metadata
Title (english)Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications
AuthorTomislav Bulum
MBZ: 332203
AuthorMarijana Vučić Lovrenčić
MBZ: 176744
AuthorMartina Tomić
MBZ: 272561
AuthorSandra Vučković Rebrina
MBZ: 177894
AuthorVinko Roso
AuthorBranko Kolarić
AuthorVladimir Vuksan
MBZ: 53962
AuthorLea Duvnjak
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Social Medicine and Epidemiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Recent studies have implicated possible contribution of adipocytokines in development and progression of microvascular complications in patients with type 1 diabetes (T1DM). The aim of our study was to investigate relationship between adipocytokines, namely leptin, resistin, adiponectin and dipeptidyl peptidase-4 (DPP-4) activity, with albuminuria in T1DM. This study included 202 T1DM without or with incipient microvascular complications. Urinary albumin excretion rate (UAE) was measured from at least two 24-h urine samples. Serum DPP-4 activity was measured by a colorimetric assay procured, and the level of adiponectin, leptin, and resistin was determined by the ELISA method. Serum DPP-4 activity and adiponectin was significantly higher in patients with normoalbuminuria compared to patients with microalbuminuria (47 vs 36 U/L, and 10.9 vs 7.3 ug/mL, respectively, p≤0.02). In multivariate logistic regression analysis adiponectin and serum DPP-4 activity was significantly associated with risk of microalbuminuria in our subjects (p≤0.04), with odds ratios of 0.72 to 0.99. However, after adjustment for age, sex, HbA1c, duration of diabetes and BMI, only serum DPP-4 activity was significantly associated with risk of microalbuminuria (p=0.008). The results of our study suggest that serum DPP-4 activity is lower in T1DM with microalbuminuria. Prospective studies are warranted to evaluate the relationship between serum DPP-4 activity and progression and development of albuminuria and nephropathy in T1DM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiabetes & Metabolic Syndrome: Clinical Research & Reviews
Numberingvol. 13, pp. 496-499
p-ISSN1871-4021
DOIhttps://doi.org/10.1016/j.dsx.2018.11.001
URN:NBNurn:nbn:hr:184:672554
Publication2019
Document URLhttp://bib.irb.hr/965217
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-03-08 14:38:47