prikaz prve stranice dokumenta Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study
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Scientific paper - Original scientific paper
Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study
European Journal of Internal Medicine, 82 (2020); 68-75. https://doi.org/10.1016/j.ejim.2020.08.005
Mikolašević, Ivana; Domislović, V; Turk Wensveen, Tamara; Delija, Božena; Klapan, Mia; Jurić, Toni; Lukić, Anđela; Mijić, A; Skenderević, N; Puž, P; Ostojić, A; Krznarić, Ž; Štimac, Davor

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Mikolašević, I., Domislović, V., Turk Wensveen, T., Delija, B., Klapan, M., Jurić, T. ... Štimac, D. (2020). Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study. European Journal of Internal Medicine, 82., 68-75. doi: 10.1016/j.ejim.2020.08.005

Mikolašević, Ivana, et al. "Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study." European Journal of Internal Medicine, vol. 82, 2020, pp. 68-75. https://doi.org/10.1016/j.ejim.2020.08.005

Mikolašević, Ivana, V Domislović, Tamara Turk Wensveen, Božena Delija, Mia Klapan, Toni Jurić, Anđela Lukić, et al. "Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study." European Journal of Internal Medicine 82 (2020): 68-75. https://doi.org/10.1016/j.ejim.2020.08.005

Mikolašević, I., et al. (2020) 'Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study', European Journal of Internal Medicine, 82, pp. 68-75. doi: 10.1016/j.ejim.2020.08.005

Mikolašević I, Domislović V, Turk Wensveen T, Delija B, Klapan M, Jurić T, and sur.. Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study. European Journal of Internal Medicine [Internet]. 2020 [cited 2024 November 04];82:68-75. doi: 10.1016/j.ejim.2020.08.005

I. Mikolašević, et al., "Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study", European Journal of Internal Medicine, vol. 82, pp. 68-75, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:345625. [Accessed: 04 November 2024]

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Metadata
Title (english)Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study
AuthorIvana Mikolašević
AuthorV Domislović
AuthorTamara Turk Wensveen
AuthorBožena Delija
AuthorMia Klapan
AuthorToni Jurić
AuthorAnđela Lukić
AuthorA Mijić
AuthorN Skenderević
AuthorP Puž
AuthorA Ostojić
AuthorŽ Krznarić
AuthorDavor Štimac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim: To investigate the prevalence and severity of nonalcoholic fatty liver disease (NAFLD) in patients with diabetes mellitus type 2 (T2DM), based on increased controlled attenuation parameter (CAP) and liver stiffness measurements obtained by transient elastography. In addition, we aimed to identify parameters that correlate with increased elastographic parameters of steatosis and fibrosis to provide a better indication when a patient with T2DM should be screened for NAFLD. Methods: We conducted prospective, cross-sectional study of 679 consecutive adult patients with diagnosed T2DM mean age 65.2±11.6. NAFLD was defined by transient elastography. In 105 patients a percutaneous liver biopsy (LB) was done. Results: The prevalence of NAFLD based on transient elastography was 83.6%. Independent factors associated with increased CAP were higher body mass index, longer T2DM duration, higher serum triglyceride, lower levels of vitamin D, higher C-reactive protein, and higher HOMA-IR. The prevalence of moderate liver fibrosis was 26.9% and advanced liver fibrosis 12.6%. Independent factors associated with moderated fibrosis based on elastography were higher body mass index and higher levels of alanine aminotransferase (ALT), while independent factors associated with advanced fibrosis were female gender, higher body mass index, higher levels of ALT, gama-glutamil transferase and C-reactive protein. Sixty-four (60.9%) of 105 patients with LB had NAFLD activity score ≥5. Regarding the presence and stages of fibrosis based on LB, moderate fibrosis was found in 29.5% of patients, while 29.5% had advanced fibrosis and 6.7% cirrhosis. Conclusion: This study supports more aggressive screening for NAFLD and fibrosis in patients with T2DM.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Internal Medicine
Numberingvol. 82, pp. 68-75
p-ISSN0953-6205
DOIhttps://doi.org/10.1016/j.ejim.2020.08.005
URN:NBNurn:nbn:hr:184:345625
Publication2020
Document URLhttp://bib.irb.hr/1107043
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-03-07 17:27:07