prikaz prve stranice dokumenta Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism
  Download
PDF 258.99 KB
Scientific paper - Original scientific paper
Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism
Environmental Research, 152 (2017); 375-385. https://doi.org/10.1016/j.envres.2016.08.035
Snoj Tratnik, Janja; Falnoga, Ingrid; Trdin, Ajda; Mazej, Darja; Fajon, Vesna; Miklavčič, Ana; Kobal, Alfred; Osredkar, Joško; Sešek Briški, Alenka; Krsnik, Mladen; Neubauer, David; Kodrič, Jana; Stropnik, Staša; Gosar, David; Lešnik Musek, Petra; Marc, Janja; Jurkovič Mlakar, Simona; Petrović, Oleg; Vlašić- Cicvarić, Inge; Prpić, Igor; Milardović, Ana; Radić Nišević, Jelena; Vuković, Danijela; Fišić, Elizabeta; Špirić, Zdravko; Horvat, Milena More authors...

Cite this document

Snoj Tratnik, J., Falnoga, I., Trdin, A., Mazej, D., Fajon, V., Miklavčič, A. ... Horvat, M. (2017). Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism. Environmental Research, 152., 375-385. doi: 10.1016/j.envres.2016.08.035

Snoj Tratnik, Janja, et al. "Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism." Environmental Research, vol. 152, 2017, pp. 375-385. https://doi.org/10.1016/j.envres.2016.08.035

Snoj Tratnik, Janja, Ingrid Falnoga, Ajda Trdin, Darja Mazej, Vesna Fajon, Ana Miklavčič, Alfred Kobal, et al. "Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism." Environmental Research 152 (2017): 375-385. https://doi.org/10.1016/j.envres.2016.08.035

Snoj Tratnik, J., et al. (2017) 'Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism', Environmental Research, 152, pp. 375-385. doi: 10.1016/j.envres.2016.08.035

Snoj Tratnik J, Falnoga I, Trdin A, Mazej D, Fajon V, Miklavčič A, and sur.. Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism. Environmental Research [Internet]. 2017 [cited 2024 November 15];152:375-385. doi: 10.1016/j.envres.2016.08.035

J. Snoj Tratnik, et al., "Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism", Environmental Research, vol. 152, pp. 375-385, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:939845. [Accessed: 15 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism
AuthorJanja Snoj Tratnik
AuthorIngrid Falnoga
AuthorAjda Trdin
AuthorDarja Mazej
AuthorVesna Fajon
AuthorAna Miklavčič
AuthorAlfred Kobal
AuthorJoško Osredkar
AuthorAlenka Sešek Briški
AuthorMladen Krsnik
AuthorDavid Neubauer
AuthorJana Kodrič
AuthorStaša Stropnik
AuthorDavid Gosar
AuthorPetra Lešnik Musek
AuthorJanja Marc
AuthorSimona Jurkovič Mlakar
AuthorOleg Petrović
AuthorInge Vlašić- Cicvarić
AuthorIgor Prpić
AuthorAna Milardović
AuthorJelena Radić Nišević
AuthorDanijela Vuković
AuthorElizabeta Fišić
MBZ: 253916
AuthorZdravko Špirić
AuthorMilena Horvat
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Environmental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Health Ecology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
The aim of the present study was to evaluate the association between prenatal exposure to mercury (Hg) and neurodevelopment of the child, taking into account genetic polymorphism of apolipoprotein E (Apoe) and other relevant confounders. Six hundred and one mother-child pairs were recruited from the central Slovenia region and 243 from Rijeka, on the Croatian coast of the northern Adriatic. The total Hg in cord blood, Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) assessment at 18 months of age and Apoe genotyping was performed on 361 children ; 237 of them were from Slovenia and 124 from Croatia. The results showed negative association between low- to-moderate Hg exposure in children with normal neurodevelopmental outcome and cognitive and fine motor scores at 18 months of age as assessed by BayleyIII. The Hg-related decrease in cognitive score was observed only in children carrying atleastone Apoe ε4 allele, while the decrease in fine motor scores was independent of the Apoe genotype. Adjusting for selenium (Se) and lead (Pb) levels, a positive association between Se and the language score and a negative association between Pb and the motor score was observed, but not in the subgroup of children carrying the ε4 allele.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionSubmitted version
Journal titleEnvironmental Research
Numberingvol. 152, pp. 375-385
p-ISSN0013-9351
DOIhttps://doi.org/10.1016/j.envres.2016.08.035
URN:NBNurn:nbn:hr:184:939845
Publication2017
Document URLhttp://bib.irb.hr/846946
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-03 18:31:14