prikaz prve stranice dokumenta Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays
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Scientific paper - Original scientific paper
Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays
Wiener klinische Wochenschrift, 129 (2017), 1/2; 33-37. https://doi.org/10.1007/s00508-016-1094-6
Katalinić, Nataša; Fućak, Marina; Crnić, Tajana; Ćurković, Milena; Starčević, Alma; Balen, Sanja

Cite this document

Katalinić, N., Fućak, M., Crnić, T., Ćurković, M., Starčević, A. & Balen, S. (2017). Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays. Wiener klinische Wochenschrift, 129. (1/2), 33-37. doi: 10.1007/s00508-016-1094-6

Katalinić, Nataša, et al. "Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays." Wiener klinische Wochenschrift, vol. 129, no. 1/2, 2017, pp. 33-37. https://doi.org/10.1007/s00508-016-1094-6

Katalinić, Nataša, Marina Fućak, Tajana Crnić, Milena Ćurković, Alma Starčević and Sanja Balen. "Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays." Wiener klinische Wochenschrift 129, no. 1/2 (2017): 33-37. https://doi.org/10.1007/s00508-016-1094-6

Katalinić, N., et al. (2017) 'Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays', Wiener klinische Wochenschrift, 129(1/2), pp. 33-37. doi: 10.1007/s00508-016-1094-6

Katalinić N, Fućak M, Crnić T, Ćurković M, Starčević A, Balen S. Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays. Wiener klinische Wochenschrift [Internet]. 2017 [cited 2024 November 11];129(1/2):33-37. doi: 10.1007/s00508-016-1094-6

N. Katalinić, M. Fućak, T. Crnić, M. Ćurković, A. Starčević and S. Balen, "Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays", Wiener klinische Wochenschrift, vol. 129, no. 1/2, pp. 33-37, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:768436. [Accessed: 11 November 2024]

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Metadata
Title (english)Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays
AuthorNataša Katalinić
AuthorMarina Fućak
AuthorTajana Crnić
AuthorMilena Ćurković
AuthorAlma Starčević
AuthorSanja Balen
MBZ: 236875
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The introduction of more sensitive techniques, such as Luminex® for HLA antibody screening of patients awaiting organ transplantation has resulted in a better understanding of transplantation immunology and improvements in clinical practice. The interpretation of the results obtained only by Luminex® can lead to inaccurate evaluation of a patient’s antibody status and unjustified rejection of a potential organ donor. The aim of this study was to demonstrate the benefits of performing HLA antibody screening in the sera of patients on the waiting list for organ transplantation by two different assays, complement dependent cytotoxicity (CDC) and Luminex®. A retrospective analysis was performed on 563 pretransplant serum samples from 141 patients on the kidney transplantation waiting list in Rijeka, tested from March 2012 until March 2015. All samples were tested in parallel by the CDC assay and the Luminex®-based assay. Out of the 563 samples tested 302 (53.7%) tested negative for HLA antibodies and 88 (15.6%) positive by both assays. From 173 (30.7%) samples with discordant results 149 (26.5%) were CDC negative and Luminex® positive, while 24 (4.3%) were CDC positive and Luminex® negative. Among the Luminex positive patients seven did not experience any immunizing events. Evaluation of the HLA antibody status in patients on a waiting list for organ transplantation should be based on the results of the both CDC and Luminex® (or other sensitive) assays in accordance to information about patient’s clinical status and exposure to immunizing events.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWiener klinische Wochenschrift
Numberingvol. 129, no. 1/2, pp. 33-37
p-ISSN0043-5325
DOIhttps://doi.org/10.1007/s00508-016-1094-6
URN:NBNurn:nbn:hr:184:768436
Publication2017
Document URLhttp://bib.irb.hr/861875
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-03 17:21:05