prikaz prve stranice dokumenta Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
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Scientific paper - Original scientific paper
Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
Molecular nutrition & food research, 60 (2016), 3; 530-541. https://doi.org/10.1002/mnfr.201500409
Potočnjak, Iva; Škoda, Marko; Pernjak-Pugel, Ester; Pavletić Peršić, Martina; Domitrović, Robert

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Potočnjak, I., Škoda, M., Pernjak Pugel, E., Pavletić Peršić, M. & Domitrović, R. (2016). Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling. Molecular nutrition & food research, 60. (3), 530-541. doi: 10.1002/mnfr.201500409

Potočnjak, Iva, et al. "Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling." Molecular nutrition & food research, vol. 60, no. 3, 2016, pp. 530-541. https://doi.org/10.1002/mnfr.201500409

Potočnjak, Iva, Marko Škoda, Ester Pernjak Pugel, Martina Pavletić Peršić and Robert Domitrović. "Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling." Molecular nutrition & food research 60, no. 3 (2016): 530-541. https://doi.org/10.1002/mnfr.201500409

Potočnjak, I., et al. (2016) 'Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling', Molecular nutrition & food research, 60(3), pp. 530-541. doi: 10.1002/mnfr.201500409

Potočnjak I, Škoda M, Pernjak Pugel E, Pavletić Peršić M, Domitrović R. Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling. Molecular nutrition & food research [Internet]. 2016 [cited 2024 May 06];60(3):530-541. doi: 10.1002/mnfr.201500409

I. Potočnjak, M. Škoda, E. Pernjak Pugel, M. Pavletić Peršić and R. Domitrović, "Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling", Molecular nutrition & food research, vol. 60, no. 3, pp. 530-541, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:827156. [Accessed: 06 May 2024]

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Metadata
Title (english)Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
AuthorIva Potočnjak
AuthorMarko Škoda
AuthorEster Pernjak-Pugel
AuthorMartina Pavletić Peršić
MBZ: 247473
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract (english)
Oleuropein possesses numerous health beneficial effects. We investigated the renoprotective effects of oleuropein against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally gavaged with 5, 10 and 20 mg oleuropein/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, serum creatinine and blood urea nitrogen (BUN) levels were significantly elevated, with histopathological changes in renal tissue. In addition, renal oxidative stress was evidenced by increased expression of 3-nitrotyrosine (3-NT), 4-hydroxynonenal (4-HNE), cytochrome P450 E1 (CYP2E1) and heme oxygenase-1 (HO-1). The expression of nuclear factor-kappaB (NF-κB) p65, phospho-p65, tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) in the kidneys increased upon CP treatment, suggesting renal inflammation. CP intoxication increased the expression of p53, Bax and caspase-3 and induced apoptosis in the kidneys. CP administration also resulted in enhanced phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). All these effects were dose-dependently diminished by oleuropein. Oral administration of PD0325901, an MEK inhibitor, coincided with the oleuropein-mediated suppression of apoptotic, inflammatory and antioxidant markers. The results of the current study suggest that oleuropein attenuated CP-induced acute renal injury, which was mediated through the inhibition of ERK signaling.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMolecular nutrition & food research
Numberingvol. 60, no. 3, pp. 530-541
p-ISSN1613-4125
DOIhttps://doi.org/10.1002/mnfr.201500409
URN:NBNurn:nbn:hr:184:827156
Publication2016
ProjectNumber: 062-0000000-3554
Title (croatian): Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre
Title (english): Medical plant active compounds in the treatment of liver fibrosis
Leader: Robert Domitrović
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 13.06.1.2.24
Title (croatian): Intereakcija fitokemikalija i lijekova in vivo: modulacija nefrotoksičnosti cisplatina
Leader: Robert Domitrović
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/767421
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-01 14:10:33