prikaz prve stranice dokumenta Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke
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Scientific paper - Original scientific paper
Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke
Wiener klinische Wochenschrift, 128 (2016), 1/2; 20-27. urn:nbn:hr:184:356412
Bonifačić, David; Toplak, Adrian; Benjak, Indira; Sotošek Tokmadžić, Vlatka; Lekić, Andrica; Kučić, Natalia

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Bonifačić, D., Toplak, A., Benjak, I., Sotošek Tokmadžić, V., Lekić, A. & Kučić, N. (2016). Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke. Wiener klinische Wochenschrift, 128. (1/2), 20-27. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:356412

Bonifačić, David, et al. "Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke." Wiener klinische Wochenschrift, vol. 128, no. 1/2, 2016, pp. 20-27. https://urn.nsk.hr/urn:nbn:hr:184:356412

Bonifačić, David, Adrian Toplak, Indira Benjak, Vlatka Sotošek Tokmadžić, Andrica Lekić and Natalia Kučić. "Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke." Wiener klinische Wochenschrift 128, no. 1/2 (2016): 20-27. https://urn.nsk.hr/urn:nbn:hr:184:356412

Bonifačić, D., et al. (2016) 'Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke', Wiener klinische Wochenschrift, 128(1/2), pp. 20-27. Available at: https://urn.nsk.hr/urn:nbn:hr:184:356412 (Accessed 12 November 2024)

Bonifačić D, Toplak A, Benjak I, Sotošek Tokmadžić V, Lekić A, Kučić N. Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke. Wiener klinische Wochenschrift [Internet]. 2016 [cited 2024 November 12];128(1/2):20-27. Available at: https://urn.nsk.hr/urn:nbn:hr:184:356412

D. Bonifačić, A. Toplak, I. Benjak, V. Sotošek Tokmadžić, A. Lekić and N. Kučić, "Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke", Wiener klinische Wochenschrift, vol. 128, no. 1/2, pp. 20-27, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:356412. [Accessed: 12 November 2024]

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Metadata
Title (english)Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke
Title (english)Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke.
AuthorDavid Bonifačić
AuthorAdrian Toplak
AuthorIndira Benjak
AuthorVlatka Sotošek Tokmadžić
AuthorAndrica Lekić
MBZ: 210501
AuthorNatalia Kučić
MBZ: 239812
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Physics and Biophysics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In this study to identify prognostic biomarkers for ischemic stroke (IS) outcome, we monitored monocyte number and monocyte chemoattractant protein (MCP-1) concentration in peripheral blood of 44 patients with IS during the week following IS. According to the severity of IS, patients were allocated to three groups: patients with transient ischemic attack (TIA), patients with National Institute of Health Stroke Scale (NIHSS) score ≤ 12, and patients with NIHSS > 12. In patients with NIHSS > 12 statistically significant increased number of monocytes was observed on day 7. MCP-1 plasma concentration initially increased, decreased at day 3 in patients with NIHSS > 12 and increased and restored on day 7. A negative correlation between the number of monocytes and MCP-1 concentration was observed on day 3 after IS. Higher day-7 MCP-1 level was associated with higher modified Rankin Scale (mRS) value (indicating worse outcome) at 90 days post-IS in patients with NIHSS > 12. Our findings suggest that number of monocytes and plasma MCP-1 level could be clinical prognostic biomarkers as early predictors of disease outcome in patients with IS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWiener klinische Wochenschrift
Numberingvol. 128, no. 1/2, pp. 20-27
p-ISSN0043-5325
URN:NBNurn:nbn:hr:184:356412
Publication2016
Document URLhttp://bib.irb.hr/812804
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-25 16:34:16