prikaz prve stranice dokumenta Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,
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Scientific paper - Original scientific paper
Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,
Breast Disease, 1(2019) (2019); 1-7. https://doi.org/10.3233/bd-180341
Tomić, Snježana; Mrklić, Ivana; Razumović, Jasminka Jakić; Jonjić, Nives; Šarčević, Božena; Blažičević, Valerija; Jurković, Ilija; Vrbičić, Branka; Lisica Šikic, Nataša; Peteh, Loredana Labinac; Lončarić, Čedna Tomasović; Vučić, Majda; Gašparov, Slavko; Švagelj, Dražen; Radiković, Sandra; Mahovne, Ivana More authors...

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Tomić, S., Mrklić, I., Razumović, J. J., Jonjić, N., Šarčević, B., Blažičević, V. ... Mahovne, I. (2019). Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,. Breast Disease, 1(2019)., 1-7. doi: 10.3233/bd-180341

Tomić, Snježana, et al. "Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,." Breast Disease, vol. 1(2019), 2019, pp. 1-7. https://doi.org/10.3233/bd-180341

Tomić, Snježana, Ivana Mrklić, Jasminka Jakić Razumović, Nives Jonjić, Božena Šarčević, Valerija Blažičević, Ilija Jurković, et al. "Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,." Breast Disease 1(2019) (2019): 1-7. https://doi.org/10.3233/bd-180341

Tomić, S., et al. (2019) 'Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,', Breast Disease, 1(2019), pp. 1-7. doi: 10.3233/bd-180341

Tomić S, Mrklić I, Razumović JJ, Jonjić N, Šarčević B, Blažičević V, and sur.. Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,. Breast Disease [Internet]. 2019 [cited 2024 May 05];1(2019):1-7. doi: 10.3233/bd-180341

S. Tomić, et al., "Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,", Breast Disease, vol. 1(2019), pp. 1-7, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:344868. [Accessed: 05 May 2024]

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Metadata
Title (english)Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis,
Title (english)Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis
AuthorSnježana Tomić
MBZ: 212900
AuthorIvana Mrklić
AuthorJasminka Jakić Razumović
AuthorNives Jonjić
AuthorBožena Šarčević
MBZ: 87995
AuthorValerija Blažičević
MBZ: 232314
AuthorIlija Jurković
AuthorBranka Vrbičić
AuthorNataša Lisica Šikic
AuthorLoredana Labinac Peteh
AuthorČedna Tomasović Lončarić
AuthorMajda Vučić
MBZ: 251431
AuthorSlavko Gašparov
MBZ: 233824
AuthorDražen Švagelj
MBZ: 224894
AuthorSandra Radiković
AuthorIvana Mahovne
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Background: Proliferation rate is a major determinant of the biologic behavior of the tumor and provides information that can be used to guide treatment decisions. Methods: This ring study included 27 pathologists from 14 Institutions, in order to assess inter-observer concordance between pathologists in Croatia. We analyzed Ki-67 proliferative index on ten randomly selected breast cancer samples comparing consistency between visual assessment using light microscopy compared to digital image analyses results from one central laboratory as a referral value. Results: When we analyzed Ki-67 as numeric value high concordance rate was found between Ki-67 score visually assessed in all participating Institutions compared to referral value assessed by digital image analysis (ICC 0.76, 95% CI 0.58-0.91), and Krippendorff's alpha was 0.79 (95% CI 0.58-1.00). Concordance was better in slides with higher Ki-67 values. When we categorized Ki-67 values according to generally accepted 20% cut-off value we noticed the lower concordance rate among participants in our study. Conclusion: Proliferation remains one of the most important parameters for tumor characterization helpful in making clinical decisions, but it should be used with great caution. Standardization of the Ki-67 assessment is essential and proliferating index should be expressed as exact numeric value. For patients with proliferative index near the cut-off value, other factors must be considered in making clinical decisions.
Keywords (croatian)
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBreast Disease
Numberingvol. 1(2019), pp. 1-7
p-ISSN0888-6008
DOIhttps://doi.org/10.3233/bd-180341
URN:NBNurn:nbn:hr:184:344868
Publication2019
Document URLhttp://bib.irb.hr/1003890
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-23 16:19:06