prikaz prve stranice dokumenta High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity
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Scientific paper - Original scientific paper
High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity
International Journal of Hematology, 112 (2020), 2; 141-146. https://doi.org/10.1007/s12185-020-02920-y
Caocci, Giovanni; Vignetti, Marco; Patriarca, Andrea; Breccia, Massimo; Platzbecker, Uwe; Palumbo, Giuseppe A.; Stauder, Reinhard; Cottone, Francesco; Petranović, Duška; Voso, Maria Teresa; Tafuri, Agostino; Invernizzi, Rosangela; Caers, Jo; Luppi, Mario; La Nasa, Giorgio; Niscola, Pasquale; Efficace, Fabio More authors...

Cite this document

Caocci, G., Vignetti, M., Patriarca, A., Breccia, M., Platzbecker, U., Palumbo, G. A. ... Efficace, F. (2020). High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity. International Journal of Hematology, 112. (2), 141-146. doi: 10.1007/s12185-020-02920-y

Caocci, Giovanni, et al. "High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity." International Journal of Hematology, vol. 112, no. 2, 2020, pp. 141-146. https://doi.org/10.1007/s12185-020-02920-y

Caocci, Giovanni, Marco Vignetti, Andrea Patriarca, Massimo Breccia, Uwe Platzbecker, Giuseppe A. Palumbo, Reinhard Stauder, et al. "High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity." International Journal of Hematology 112, no. 2 (2020): 141-146. https://doi.org/10.1007/s12185-020-02920-y

Caocci, G., et al. (2020) 'High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity', International Journal of Hematology, 112(2), pp. 141-146. doi: 10.1007/s12185-020-02920-y

Caocci G, Vignetti M, Patriarca A, Breccia M, Platzbecker U, Palumbo GA, and sur.. High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity. International Journal of Hematology [Internet]. 2020 [cited 2024 July 08];112(2):141-146. doi: 10.1007/s12185-020-02920-y

G. Caocci, et al., "High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity", International Journal of Hematology, vol. 112, no. 2, pp. 141-146, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:372655. [Accessed: 08 July 2024]

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Metadata
Title (english)High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity
AuthorGiovanni Caocci
AuthorMarco Vignetti
AuthorAndrea Patriarca
AuthorMassimo Breccia
AuthorUwe Platzbecker
AuthorGiuseppe A. Palumbo
AuthorReinhard Stauder
AuthorFrancesco Cottone
AuthorDuška Petranović
AuthorMaria Teresa Voso
AuthorAgostino Tafuri
AuthorRosangela Invernizzi
AuthorJo Caers
AuthorMario Luppi
AuthorGiorgio La Nasa
AuthorPasquale Niscola
AuthorFabio Efficace
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We examined the association between serum ferritin (SF) levels and patient-reported functional aspects and symptoms, as measured by the EORTC QLQ-C30, in newly diagnosed patients with myelodysplastic syndromes (MDS). Analysis was conducted on 497 MDS patients who were classified in two groups based on the SF value of 1000 ng/mL. Clinically relevant differences of patient-reported functional and symptom scales were evaluated and classified as small, medium and large, based on established thresholds. Multivariable linear regression analysis was performed to account for potential confounding factors. Patients with SF of ≥ 1000 ng/mL reported statistically significant and clinically relevant worse outcomes across various health domains. Dyspnea was the symptom indicating the largest difference and mean scores of patients with higher and lower SF levels were 40 and 24.3, respectively (p = 0.005), indicating a large clinically relevant difference (Δ = 15.7). Further research is needed to better understand the relationship between SF levels and specific health-related quality of life domains.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Hematology
Numberingvol. 112, no. 2, pp. 141-146
p-ISSN0925-5710
DOIhttps://doi.org/10.1007/s12185-020-02920-y
URN:NBNurn:nbn:hr:184:372655
Publication2020
Document URLhttp://bib.irb.hr/1107118
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-22 07:30:04