prikaz prve stranice dokumenta Donor-specific antibodies require preactivated immune system to harm renal transplant
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Scientific paper - Original scientific paper
Donor-specific antibodies require preactivated immune system to harm renal transplant
EBioMedicine, 9 (2016); 366-371. https://doi.org/10.1016/j.ebiom.2016.06.006
Süsal, Caner; ...; ...; ...; ...; ...; ...; ...; ...; Balen, Sanja; Živčić-Ćosić, Stela; ...; ...; ...; ...; ...; ...; ...; ...; ...; ...; ...; ...; Opelz, Gerhard More authors...

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Süsal, C., Balen, S., Živčić Ćosić, S. & Opelz, G. (2016). Donor-specific antibodies require preactivated immune system to harm renal transplant. EBioMedicine, 9., 366-371. doi: 10.1016/j.ebiom.2016.06.006

Süsal, Caner, et al. "Donor-specific antibodies require preactivated immune system to harm renal transplant." EBioMedicine, vol. 9, 2016, pp. 366-371. https://doi.org/10.1016/j.ebiom.2016.06.006

Süsal, Caner, Sanja Balen, Stela Živčić Ćosić and Gerhard Opelz. "Donor-specific antibodies require preactivated immune system to harm renal transplant." EBioMedicine 9 (2016): 366-371. https://doi.org/10.1016/j.ebiom.2016.06.006

Süsal, C., et al. (2016) 'Donor-specific antibodies require preactivated immune system to harm renal transplant', EBioMedicine, 9, pp. 366-371. doi: 10.1016/j.ebiom.2016.06.006

Süsal C, Balen S, Živčić Ćosić S, Opelz G. Donor-specific antibodies require preactivated immune system to harm renal transplant. EBioMedicine [Internet]. 2016 [cited 2024 December 27];9:366-371. doi: 10.1016/j.ebiom.2016.06.006

C. Süsal, S. Balen, S. Živčić Ćosić and G. Opelz, "Donor-specific antibodies require preactivated immune system to harm renal transplant", EBioMedicine, vol. 9, pp. 366-371, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:445418. [Accessed: 27 December 2024]

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Metadata
Title (english)Donor-specific antibodies require preactivated immune system to harm renal transplant
AuthorCaner Süsal
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AuthorSanja Balen
MBZ: 236875
AuthorStela Živčić-Ćosić
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AuthorGerhard Opelz
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to exert a deleterious effect. Methods The impact of pretransplant DSA and immune activation marker soluble CD30 (sCD30) on 3-year graft survival was analyzed in 385 presensitized kidney transplant recipients. Findings A deleterious influence of pretransplant DSA on graft survival was evident only in patients who were positive for the immune activation marker sCD30. In the absence of sCD30 positivity, 3-year graft survival was virtually identical in patients with or without DSA (83·1±3·9% and 84·3±2·8%, P=0·81). A strikingly lower 3-year graft survival rate of 62·1±6·4% was observed in patients who were both sCD30 and DSA positive (HR 2·92, P<0·001). Even in the presence of strong DSA with ≥5, 000 MFI, the 3-year graft survival rate was high if the recipients were sCD30 negative. Interpretation Pretransplant DSA have a significantly deleterious impact on graft survival only in the presence of high pretransplant levels of the activation marker sCD30.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEBioMedicine
Numberingvol. 9, pp. 366-371
p-ISSN2352-3964
DOIhttps://doi.org/10.1016/j.ebiom.2016.06.006
URN:NBNurn:nbn:hr:184:445418
Publication2016
Document URLhttp://bib.irb.hr/820647
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-17 09:27:45