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Scientific paper - Case study
Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?
Signa Vitae, 16 (2020); 183-185. urn:nbn:hr:184:903977
Bilić Čače, Iva; Milardović, Ana; Nikolić, Harry; Bosak Veršić, Ana; Butorac Ahel, Ivona

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Bilić Čače, I., Milardović, A., Nikolić, H., Bosak Veršić, A. & Butorac Ahel, I. (2020). Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?. Signa Vitae, 16., 183-185. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:903977

Bilić Čače, Iva, et al. "Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?." Signa Vitae, vol. 16, 2020, pp. 183-185. https://urn.nsk.hr/urn:nbn:hr:184:903977

Bilić Čače, Iva, Ana Milardović, Harry Nikolić, Ana Bosak Veršić and Ivona Butorac Ahel. "Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?." Signa Vitae 16 (2020): 183-185. https://urn.nsk.hr/urn:nbn:hr:184:903977

Bilić Čače, I., et al. (2020) 'Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?', Signa Vitae, 16, pp. 183-185. Available at: https://urn.nsk.hr/urn:nbn:hr:184:903977 (Accessed 07 May 2024)

Bilić Čače I, Milardović A, Nikolić H, Bosak Veršić A, Butorac Ahel I. Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?. Signa Vitae [Internet]. 2020 [cited 2024 May 07];16:183-185. Available at: https://urn.nsk.hr/urn:nbn:hr:184:903977

I. Bilić Čače, A. Milardović, H. Nikolić, A. Bosak Veršić and I. Butorac Ahel, "Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?", Signa Vitae, vol. 16, pp. 183-185, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:903977. [Accessed: 07 May 2024]

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Metadata
Title (english)Could the Implantation of Dextranomer/Hyaluronic Acid Cause the Elevation of Neuron-Specific Enolase in Children Treated for Vesicoureteral Reflux?
AuthorIva Bilić Čače
AuthorAna Milardović
AuthorHarry Nikolić
AuthorAna Bosak Veršić
AuthorIvona Butorac Ahel
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Background: Dextranomer/hyaluronic acid copolymer (Dx/HA) has been the most widely used bulking agent for the endoscopic treatment of vesicoureteral reflux. Case presentation: Here we report on a case of an 18-month-old male who underwent endoscopic treatment with Dx/HA for persistent high-grade unilateral vesicoureteral reflux (VUR). Three months later, due to the reappearance of contralateral VUR and indicated endoscopic treatment, a second cystoscopy was performed. A submucosal, well-vascularized mass localized on the left trigone and anteromedially to the left orifice was noted. Since it differed from the other similar implants previously detected on cystoscopy, it was misdiagnosed with a bladder tumor, indicating further evaluation. Extensive laboratory and imaging studies revealed normal findings, apart from high levels of neuron- specific enolase (NSE). A hypothesis made at that point was that the elevated level of NSE is due to the implantation of the Dx/HA. To test the hypothesis, two other healthy children previously treated with a Dx/HA implant were identified and their NSE levels measured. In both cases, the levels of NSE were elevated. Conclusion: The presented cases revealed that elevated levels of NSE are most likely due to a previous implantation of Dx/HA. This observation should be taken into consideration whenever there is a tentative diagnosis of bladder tumor following the endoscopic treatment of VUR with Dx/HA in a child.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleSigna Vitae
Numberingvol. 16, pp. 183-185
p-ISSN1334-5605
URN:NBNurn:nbn:hr:184:903977
Publication2020
Document URLhttp://bib.irb.hr/1078198
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-14 17:11:11