Concurrent elevations of VEGF, osteopontin and 
MCP-1 serum levels are independent predictors of 
survival in patients with Diffuse large B- Cell 
lymphoma

Duletić-Načinović, Antica; Gačić, Vedrana; Valković, Toni; Lučin, Ksenija; Fišić, Elizabeta; Žuvić-Butorac, Marta; Seili- Bekafigo, Irena; Jonjić, Nives

doi:10.1159/000444624

prikaz prve stranice dokumenta Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma

Scientific paper - Original scientific paper

Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma

Acta Haematologica, 136 (2016), 1; 52-61. https://doi.org/10.1159/000444624

Duletić-Načinović, Antica; Gačić, Vedrana; Valković, Toni; Lučin, Ksenija; Fišić, Elizabeta; Žuvić-Butorac, Marta; Seili- Bekafigo, Irena; Jonjić, Nives

Cite this document

APA 6th Edition

Duletić Načinović, A., Gačić, V., Valković, T., Lučin, K., Fišić, E., Žuvić Butorac, M. ... Jonjić, N. (2016). Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma. Acta Haematologica, 136. (1), 52-61. doi: 10.1159/000444624

MLA 8th Edition

Duletić Načinović, Antica, et al. "Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma." Acta Haematologica, vol. 136, no. 1, 2016, pp. 52-61. https://doi.org/10.1159/000444624

Chicago 17th Edition

Duletić Načinović, Antica, Vedrana Gačić, Toni Valković, Ksenija Lučin, Elizabeta Fišić, Marta Žuvić Butorac, Irena Seili Bekafigo and Nives Jonjić. "Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma." Acta Haematologica 136, no. 1 (2016): 52-61. https://doi.org/10.1159/000444624

Harvard

Duletić Načinović, A., et al. (2016) 'Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma', Acta Haematologica, 136(1), pp. 52-61. doi: 10.1159/000444624

Vancouver

Duletić Načinović A, Gačić V, Valković T, Lučin K, Fišić E, Žuvić Butorac M, and sur.. Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma. Acta Haematologica [Internet]. 2016 [cited 2024 December 02];136(1):52-61. doi: 10.1159/000444624

IEEE

A. Duletić Načinović, et al., "Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma", Acta Haematologica, vol. 136, no. 1, pp. 52-61, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:964701. [Accessed: 02 December 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:964701

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Metadata

Title (english)	Concurrent elevations of VEGF, osteopontin and MCP-1 serum levels are independent predictors of survival in patients with Diffuse large B- Cell lymphoma
Author	Antica Duletić-Načinović
Author	Vedrana Gačić
Author	Toni Valković
Author	Ksenija Lučin
Author	Elizabeta Fišić MBZ: 253916
Author	Marta Žuvić-Butorac
Author	Irena Seili- Bekafigo
Author	Nives Jonjić
Author's institution	University of Rijeka Faculty of Medicine (Department of Internal Medicine)
Author's institution	University of Rijeka Faculty of Medicine (Department of General Pathology and Pathological Anatomy)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Diffuse large B-cell lymphomas (DLBCL) are heterogeneous diseases, and the identification of additional DLBCL risk factors is especially important. METHODS: In this pilot study, we determined pretreatment serum levels of vascular endothelial growth factor (VEGF), osteopontin (OPN) and macrophage chemotactic protein-1 (MCP- 1) in 67 newly diagnosed DLBCL patients before treatment with standard chemoimmunotherapy and in 30 healthy persons. RESULTS: Serum levels of all three cytokines were significantly elevated in untreated patients compared to controls. VEGF and OPN concentrations were higher in patients with advanced Ann Arbor stage, B symptoms, Eastern Cooperative Oncology Group score ≥2, International Prognostic Index (IPI) ≥3 and partial/no remission. A high MCP-1 level was associated with advanced stage, increased IPI and bone marrow infiltration. In univariate analysis, elevated OPN and VEGF, and concurrent elevation of all three biomarkers, were identified as significant predictors of poor survival. Multivariate Cox analysis revealed that elevated OPN combined with elevated VEGF levels was one of the best parameter subsets predicting poorest survival. According to our preliminary results, serum levels of VEGF and OPN before treatment predict response to therapy and survival after chemoimmunotherapy, and may help to further stratify DLBCL patients into risk groups.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Acta Haematologica
Numbering	vol. 136, no. 1, pp. 52-61
p-ISSN	0001-5792
e-ISSN	1421-9662
DOI	https://doi.org/10.1159/000444624
URN:NBN	urn:nbn:hr:184:964701
Publication	2016
Document URL	http://bib.irb.hr/820211
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2022-02-14 12:03:27