Colocalization of Granulysin Protein Forms with 
Perforin and LAMP-1 in Decidual Lymphocytes 
During Early Pregnancy

Dominović, Marin; Laškarin, Gordana; Glavan Gačanin, Lana; Haller, Herman; Rukavina, Daniel

doi:10.1111/aji.12503

prikaz prve stranice dokumenta Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy

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Scientific paper - Original scientific paper

Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy

American Journal of Reproductive Immunology, 75 (2016), 6; 619-630. https://doi.org/10.1111/aji.12503

Dominović, Marin; Laškarin, Gordana; Glavan Gačanin, Lana; Haller, Herman; Rukavina, Daniel

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APA 6th Edition

Dominović, M., Laškarin, G., Glavan Gačanin, L., Haller, H. & Rukavina, D. (2016). Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy. American Journal of Reproductive Immunology, 75. (6), 619-630. doi: 10.1111/aji.12503

MLA 8th Edition

Dominović, Marin, et al. "Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy." American Journal of Reproductive Immunology, vol. 75, no. 6, 2016, pp. 619-630. https://doi.org/10.1111/aji.12503

Chicago 17th Edition

Dominović, Marin, Gordana Laškarin, Lana Glavan Gačanin, Herman Haller and Daniel Rukavina. "Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy." American Journal of Reproductive Immunology 75, no. 6 (2016): 619-630. https://doi.org/10.1111/aji.12503

Harvard

Dominović, M., et al. (2016) 'Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy', American Journal of Reproductive Immunology, 75(6), pp. 619-630. doi: 10.1111/aji.12503

Vancouver

Dominović M, Laškarin G, Glavan Gačanin L, Haller H, Rukavina D. Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy. American Journal of Reproductive Immunology [Internet]. 2016 [cited 2024 October 05];75(6):619-630. doi: 10.1111/aji.12503

IEEE

M. Dominović, G. Laškarin, L. Glavan Gačanin, H. Haller and D. Rukavina, "Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy", American Journal of Reproductive Immunology, vol. 75, no. 6, pp. 619-630, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:681638. [Accessed: 05 October 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:681638

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Title (english)	Colocalization of Granulysin Protein Forms with Perforin and LAMP-1 in Decidual Lymphocytes During Early Pregnancy
Author	Marin Dominović MBZ: 316571
Author	Gordana Laškarin
Author	Lana Glavan Gačanin
Author	Herman Haller
Author	Daniel Rukavina
Author's institution	University of Rijeka Faculty of Medicine (Department of Physiology, Immunology and Pathophxsiology)
Author's institution	University of Rijeka Faculty of Medicine (Department of Gynaecology and Obstetrics)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Immunology
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Human Physiology
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	PROBLEM: Granulysin (GNLY) occurs in two forms, which have molecular weights of 9 and 15 kDa. We analyzed the cytotoxic potential of decidual lymphocytes (DLs) and peripheral blood lymphocytes (PBLs) based on the forms of GNLY that colocalizes with perforin (PER) and LAMP-1 following activation. METHODS: The forms of GNLY were detected by using confocal microscopy. We investigated the colocalization with PER and LAMP-1 in freshly isolated and activated DLs and PBLs. RESULTS: Activation of DLs and PBLs by K- 562 cells increased the colocalization of 9 kDa GNLY with PER and LAMP- 1. K-562 cells transfected with HLA-C decreased 9 kDa GNLY colocalization with PER in DLs only. IL-15 in DLs decreased 9 kDa GNLY and LAMP-1 colocalization, but increased both 15 kDa GNLY and LAMP-1, and PER and LAMP-1 colocalization. CONCLUSION: Activated DLs and PBLs show greater cytotoxic potential based on increased colocalization of 9 kDa GNLY and PER. HLA-C and IL-15 affect DLs, indicating their role in maintaining the pregnancy tolerance.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	American Journal of Reproductive Immunology
Numbering	vol. 75, no. 6, pp. 619-630
p-ISSN	1046-7408
e-ISSN	1600-0897
DOI	https://doi.org/10.1111/aji.12503
URN:NBN	urn:nbn:hr:184:681638
Publication	2016
Document URL	http://bib.irb.hr/817020
Type of resource	Text
Access conditions	Restricted access
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Created on	2022-02-11 16:32:17