prikaz prve stranice dokumenta An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population
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Scientific paper - Original scientific paper
An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population
Prostaglandins leukotrienes and essential fatty acids, 121 (2017); 57-59. https://doi.org/10.1016/j.plefa.2017.06.003
Nadalin, Sergej; Buretić-Tomljanović, Alena

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Nadalin, S. & Buretić Tomljanović, A. (2017). An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population. Prostaglandins leukotrienes and essential fatty acids, 121., 57-59. doi: 10.1016/j.plefa.2017.06.003

Nadalin, Sergej and Alena Buretić Tomljanović. "An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population." Prostaglandins leukotrienes and essential fatty acids, vol. 121, 2017, pp. 57-59. https://doi.org/10.1016/j.plefa.2017.06.003

Nadalin, Sergej and Alena Buretić Tomljanović. "An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population." Prostaglandins leukotrienes and essential fatty acids 121 (2017): 57-59. https://doi.org/10.1016/j.plefa.2017.06.003

Nadalin, S. and Buretić Tomljanović, A. (2017) 'An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population', Prostaglandins leukotrienes and essential fatty acids, 121, pp. 57-59. doi: 10.1016/j.plefa.2017.06.003

Nadalin S, Buretić Tomljanović A. An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population. Prostaglandins leukotrienes and essential fatty acids [Internet]. 2017 [cited 2024 November 12];121:57-59. doi: 10.1016/j.plefa.2017.06.003

S. Nadalin and A. Buretić Tomljanović, "An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population", Prostaglandins leukotrienes and essential fatty acids, vol. 121, pp. 57-59, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:512171. [Accessed: 12 November 2024]

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Metadata
Title (english)An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population
AuthorSergej Nadalin
AuthorAlena Buretić-Tomljanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia and 191 controls in a Croatian population. We hypothesized that these polymorphic variations might influence the age of schizophrenia onset and Positive and Negative Syndrome Scale psychopathology (PANSS) data. We detected a significant overrepresentation of the PLA2G6-CT and PLA2G4C-AT genotype combination in patients compared with controls (14.7% vs. 7.3%, P < 0.05). The combined PLA2G6/PLA2G4C heterozygosity was associated with about a two-fold higher schizophrenia risk. We found no significant influence of the PLA2G6 and PLA2G4C polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C polymorphism accounted for approximately 12% of negative symptom severity ; whereas, the PLA2G6/PLA2G4C interaction contributed to a similar extent to total PANSS symptom variations.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleProstaglandins leukotrienes and essential fatty acids
Numberingvol. 121, pp. 57-59
p-ISSN0952-3278
DOIhttps://doi.org/10.1016/j.plefa.2017.06.003
URN:NBNurn:nbn:hr:184:512171
Publication2017
Document URLhttp://bib.irb.hr/882222
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-07 11:47:28