prikaz prve stranice dokumenta Activation of αSMA expressing perivascular cells during reactionary dentinogenesis
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Scientific paper - Original scientific paper
Activation of αSMA expressing perivascular cells during reactionary dentinogenesis
International Endodontic Journal, 52 (2019), 1; 68-76. https://doi.org/10.1111/iej.12983
Vidovic-Zdrilic, Ivana; Vijaykumar, A.; Mina, M.

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Vidovic Zdrilic, I., Vijaykumar, A. & Mina, M. (2019). Activation of αSMA expressing perivascular cells during reactionary dentinogenesis. International Endodontic Journal, 52. (1), 68-76. doi: 10.1111/iej.12983

Vidovic Zdrilic, Ivana, et al. "Activation of αSMA expressing perivascular cells during reactionary dentinogenesis." International Endodontic Journal, vol. 52, no. 1, 2019, pp. 68-76. https://doi.org/10.1111/iej.12983

Vidovic Zdrilic, Ivana, A. Vijaykumar and M. Mina. "Activation of αSMA expressing perivascular cells during reactionary dentinogenesis." International Endodontic Journal 52, no. 1 (2019): 68-76. https://doi.org/10.1111/iej.12983

Vidovic Zdrilic, I., Vijaykumar, A. and Mina, M. (2019) 'Activation of αSMA expressing perivascular cells during reactionary dentinogenesis', International Endodontic Journal, 52(1), pp. 68-76. doi: 10.1111/iej.12983

Vidovic Zdrilic I, Vijaykumar A, Mina M. Activation of αSMA expressing perivascular cells during reactionary dentinogenesis. International Endodontic Journal [Internet]. 2019 [cited 2024 November 11];52(1):68-76. doi: 10.1111/iej.12983

I. Vidovic Zdrilic, A. Vijaykumar and M. Mina, "Activation of αSMA expressing perivascular cells during reactionary dentinogenesis", International Endodontic Journal, vol. 52, no. 1, pp. 68-76, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:447452. [Accessed: 11 November 2024]

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Metadata
Title (english)Activation of αSMA expressing perivascular cells during reactionary dentinogenesis
AuthorIvana Vidovic-Zdrilic
AuthorA. Vijaykumar
AuthorM. Mina
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Aim: To examine the contribution of perivascular cells expressing αSMA to reactionary dentinogenesis. Methodology: An inducible, Cre-loxP in vivo fate- mapping approach was used to examine the contribution of the descendants of cells expressing the αSMA-CreERT2 transgene to reactionary dentinogenesis in mice molars. Reactionary dentinogenesis was induced by experimental mild injury to dentine without pulp exposure. The Student's t test was used to determine statistical significance at *P ≤ 0.05. Results: The lineage tracing experiments revealed that mild injury to dentine first led to activation of αSMA-tdTomato+ cells in the entire pulp chamber. The percentage of areas occupied by αSMA-tdTomato+ in injured (7.5 ± 0.7%) teeth were significantly higher than in teeth without injury (2 ± 0.5%). After their activation, αSMA- tdTomato+ cells migrated towards the site of injury, gave rise to pulp cells and a few odontoblasts that became integrated into the existing odontoblast layer expressing Col2.3-GFP and Dspp. Conclusion: Mild insult to dentine activated perivascular αSMA-tdTomato+ cells giving rise to pulp cells as well as a few odontoblasts that were integrated into the pre-existing odontoblast layer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Endodontic Journal
Numberingvol. 52, no. 1, pp. 68-76
p-ISSN0143-2885
DOIhttps://doi.org/10.1111/iej.12983
URN:NBNurn:nbn:hr:184:447452
Publication2019
Document URLhttp://bib.irb.hr/1048534
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-04 07:47:20