Aim: The aims of this study were to compare mEGFR status with glottic tumor TNM classification, to determine whether patients who present metastases have more or less expressed mEGFR, and to determine whether higher expression of mEGFR increases the need for neck dissection and radiation, if yes, to determine whether total laryngectomy is more often performed due to increased mEGFR. Patients and Methods: This is a retrospective study which included 20 patients aged 53-81 years who were treated for glottic squamous cell carcinoma at the Clinical Hosptal Center Rijeka. mEGFR expression level in tumor cells was measured by immunohistochemistry. Results: The results showed that the higher TNM was associated with higher expression of mEGFR. Comparison of mEGFR expression with tumor groups showed that mEGFR expression was significantly higher in advanced glottic cancer. mEGFR expression in patients with metastases was higher than mEGFR expression in patients without metastases, but the difference was not statistically significant (due to the small sample size further research is needed). m-EGFR expression was not associated with the decision if neck dissection is needed. Considering the type of operation, it was obvious that in the group with undergone total laryngectomy mEGFR expression was significantly higher. mEGFR expression was not associated with the decision if radiation is needed. Conclusion: The expression of mEGFR is associated with a worse prognosis and further research is needed in order to improve the abilities of treatment, survival and quality of life in patients with glottic cancer.