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Scientific paper - Review paper
Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva
Arhiv za higijenu rada i toksikologiju, 63 (2012), 1; 75-99. https://doi.org/10.2478/10004-1254-63-2012-2185
Batičić Pučar, Lara; Detel, Dijana; Varljen, Jadranka

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Batičić Pučar, L., Detel, D. & Varljen, J. (2012). Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva. Arhiv za higijenu rada i toksikologiju, 63. (1), 75-99. doi: 10.2478/10004-1254-63-2012-2185

Batičić Pučar, Lara, et al. "Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva." Arhiv za higijenu rada i toksikologiju, vol. 63, no. 1, 2012, pp. 75-99. https://doi.org/10.2478/10004-1254-63-2012-2185

Batičić Pučar, Lara, Dijana Detel and Jadranka Varljen. "Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva." Arhiv za higijenu rada i toksikologiju 63, no. 1 (2012): 75-99. https://doi.org/10.2478/10004-1254-63-2012-2185

Batičić Pučar, L., Detel, D. and Varljen, J. (2012) 'Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva', Arhiv za higijenu rada i toksikologiju, 63(1), pp. 75-99. doi: 10.2478/10004-1254-63-2012-2185

Batičić Pučar L, Detel D, Varljen J. Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva. Arhiv za higijenu rada i toksikologiju [Internet]. 2012 [cited 2024 November 16];63(1):75-99. doi: 10.2478/10004-1254-63-2012-2185

L. Batičić Pučar, D. Detel and J. Varljen, "Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva", Arhiv za higijenu rada i toksikologiju, vol. 63, no. 1, pp. 75-99, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:852216. [Accessed: 16 November 2024]

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Metadata
Title (croatian)Dipeptidil-peptidaza IV (DPP IV/CD26) i upalne bolesti crijeva
Title (english)Dipeptidyl Peptidase IV in Inflammatory Bowel Diseases (DPP IV/CD26)
AuthorLara Batičić Pučar
AuthorDijana Detel
AuthorJadranka Varljen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (croatian)
Upalne bolesti crijeva (Crohnova bolest, ulcerozni kolitis, nedeterminirani kolitis) skupina su kroničnih autoimunosnih upalnih bolesti obilježenih ponavljanim upalama različitih dijelova gastrointestinalnog trakta koje su važan javnozdravstveni problem današnjice. Unatoč brojnim temeljnim i kliničkim istraživanjima etiologija ovih bolesti, kao i sama patogeneza upale ostaju nedovoljno razjašnjene. Dosadašnja su istraživanja potvrdila uzročno-posljedičnu vezu između medijatora upalnog odgovora i molekula uključenih u regulaciju njihove biološke aktivnosti, osobito proteaza. Cilj ovoga preglednog rada jest sažeti prikaz dosadašnjih saznanja o različitim aspektima upalnih bolesti crijeva, s posebnim naglaskom na potencijalnu ulogu i uključenost dipeptidil-peptidaze IV, odnosno molekule CD26 (DPP IV/CD26) u mehanizme nastanka upalnih procesa u probavnom sustavu. Dan je i pregled životinjskih modela kolitisa koji su znatno pridonijeli razumijevanju i terapiji ovih bolesti, s osobitim naglaskom na mišji model ulceroznog kolitisa (DSS-kolitis) te Crohnove bolesti (TNBS-kolitis).
Abstract (english)
Infl ammatory bowel diseases (Crohn’s disease, ulcerative colitis, undetermined colitis) are a group of chronic autoimmune inflammatory diseases distinguished by recurrent inflammation of various parts of the gastrointestinal (GI) system and presenting a significant public health problem. Despite large basic and clinical research, the aetiology of these diseases and the pathogenesis of inflammation itself remain elusive. Previous studies have confirmed a causal relationship between mediators of inflammatory response and molecules involved in the regulation of their biological activity, especially proteases. The aim of this review is to summarise earlier findings on different aspects of inflammatory bowel diseases, paying particular attention to the involvement of dipeptidyl peptidase IV (CD26 molecule, DPP IV/CD26) in the etiopathogenesis of inflammatory processes in the GI tract. Animal studies of colitis have significantly contributed to the understanding and treatment of these diseases, investigations of ulcerative colitis (DSS-colitis) and Crohn’s disease (TNBS-colitis) on the murine model in particular.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 63, no. 1, pp. 75-99
p-ISSN0004-1254
e-ISSN1848-6312
DOIhttps://doi.org/10.2478/10004-1254-63-2012-2185
URN:NBNurn:nbn:hr:184:852216
Publication2012
ProjectNumber: 062-0061245-0213
Title (croatian): Uloga dipeptidil-peptidaze IV (CD26/DPP IV) u kroničnim bolestima
Title (english): The role of dipeptidyl peptidase IV (CD26/DPP IV) in chronic diseases
Leader: Jadranka Varljen
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://hrcak.srce.hr/78649
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-01-27 16:06:41