prikaz prve stranice dokumenta MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
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Scientific paper - Original scientific paper
MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
Cellular & Molecular Immunology, 7 (2022); 1-11. https://doi.org/10.1038/s41423-021-00814-5
Kim, Yeonsu; Zheng, Xiaoyan; Eschke, Kathrin; Chaudhry, M. Zeeshan; Bertoglio, Federico; Tomić, Adriana; Krmpotić, Astrid; Hoffmann, Markus; Bar-On, Yotam; Boehme, Julia D.; Bruder, Dunja; Ebensen, Thomas; Brunotte, Linda; Ludwig, Stephan; Messerle, Martin; Guzman, Carlos; Mandelboim, Ofer; Hust, Michael; Pöhlmann, Stefan; Jonjić, Stipan; Čičin-Šain, Luka More authors...

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Kim, Y., Zheng, X., Eschke, K., Chaudhry, M. Z., Bertoglio, F., Tomić, A. ... Čičin Šain, L. (2022). MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular & Molecular Immunology, 7., 1-11. doi: 10.1038/s41423-021-00814-5

Kim, Yeonsu, et al. "MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination." Cellular & Molecular Immunology, vol. 7, 2022, pp. 1-11. https://doi.org/10.1038/s41423-021-00814-5

Kim, Yeonsu, Xiaoyan Zheng, Kathrin Eschke, M. Zeeshan Chaudhry, Federico Bertoglio, Adriana Tomić, Astrid Krmpotić, et al. "MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination." Cellular & Molecular Immunology 7 (2022): 1-11. https://doi.org/10.1038/s41423-021-00814-5

Kim, Y., et al. (2022) 'MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination', Cellular & Molecular Immunology, 7, pp. 1-11. doi: 10.1038/s41423-021-00814-5

Kim Y, Zheng X, Eschke K, Chaudhry MZ, Bertoglio F, Tomić A, and sur.. MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular & Molecular Immunology [Internet]. 2022 January 07 [cited 2024 December 25];7:1-11. doi: 10.1038/s41423-021-00814-5

Y. Kim, et al., "MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination", Cellular & Molecular Immunology, vol. 7, pp. 1-11, January 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:858092. [Accessed: 25 December 2024]

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Metadata
Title (english)MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
AuthorYeonsu Kim
AuthorXiaoyan Zheng
AuthorKathrin Eschke
AuthorM. Zeeshan Chaudhry
AuthorFederico Bertoglio
AuthorAdriana Tomić
AuthorAstrid Krmpotić
AuthorMarkus Hoffmann
AuthorYotam Bar-On
AuthorJulia D. Boehme
AuthorDunja Bruder
AuthorThomas Ebensen
AuthorLinda Brunotte
AuthorStephan Ludwig
AuthorMartin Messerle
AuthorCarlos Guzman
AuthorOfer Mandelboim
AuthorMichael Hust
AuthorStefan Pöhlmann
AuthorStipan Jonjić
AuthorLuka Čičin-Šain
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Abstract Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality. There remains a medical need for vaccines against these pathogens. CMV (cytomegalovirus) is a β-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8 T cells are maintained for a lifetime. Hence, CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous pathogens. We generated two recombinant murine CMV (MCMV) vaccine vectors expressing hemagglutinin (HA) of influenza A virus (MCMV ) or the spike protein of severe acute respiratory syndrome coronavirus 2 (MCMV ). A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses, which strengthened over time. Importantly, MCMV -vaccinated mice were protected from illness following challenge with the influenza virus, and we excluded that this protection was due to the effects of memory T cells. Conclusively, we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCellular & Molecular Immunology
Numberingvol. 7, pp. 1-11
p-ISSN1672-7681
e-ISSN2042-0226
DOIhttps://doi.org/10.1038/s41423-021-00814-5
URN:NBNurn:nbn:hr:184:858092
Online first2022-01-07
Document URLhttps://www.nature.com/articles/s41423-021-00814-5
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-01-26 11:32:46