prikaz prve stranice dokumenta Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
  Download
PDF 9.98 MB
Scientific paper - Review paper
Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
Pathogens, 10 (2021), 8; 1062. https://doi.org/10.3390/pathogens10081062
Moulden, Jerome; Sung, Cathy Yea Won; Brizić, Ilija; Jonjić, Stipan; Britt, William J.

Cite this document

Moulden, J., Sung, C. Y. W., Brizić, I., Jonjić, S. & Britt, W. J. (2021). Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections. Pathogens, 10. (8). doi: 10.3390/pathogens10081062

Moulden, Jerome, et al. "Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections." Pathogens, vol. 10, no. 8, 2021. https://doi.org/10.3390/pathogens10081062

Moulden, Jerome, Cathy Yea Won Sung, Ilija Brizić, Stipan Jonjić and William J. Britt. "Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections." Pathogens 10, no. 8 (2021). https://doi.org/10.3390/pathogens10081062

Moulden, J., et al. (2021) 'Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections', Pathogens, 10(8). doi: 10.3390/pathogens10081062

Moulden J, Sung CYW, Brizić I, Jonjić S, Britt WJ. Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections. Pathogens [Internet]. 2021 August 21 [cited 2024 September 09];10(8). doi: 10.3390/pathogens10081062

J. Moulden, C. Y. W. Sung, I. Brizić, S. Jonjić and W. J. Britt, "Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections", Pathogens, vol. 10, no. 8, August 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:156194. [Accessed: 09 September 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
AuthorJerome Moulden
AuthorCathy Yea Won Sung
AuthorIlija Brizić
AuthorStipan Jonjić
AuthorWilliam J. Britt
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus infection of the developing fetus is a leading cause of neurodevelopmental disorders in infants and children, leading to long-term neurological sequela in a significant number of infected children. Current understanding of the neuropathogenesis of this intrauterine infection is limited because of the complexity of this infection, which includes maternal immunological responses that are overlaid on virus replication in the CNS during neurodevelopment. Furthermore, available data from human cases are observational, and tissues from autopsy studies have been derived from only the most severe infections. Animal models of this human infection are also limited by the strict species specificity of cytomegaloviruses. However, informative models including non-human primates and small animal models have been developed. These include several different murine models of congenital HCMV infection for the study of CMV neuropathogenesis. Although individual murine models do not completely recapitulate all aspects of the human infection, each model has provided significant information that has extended current understanding of the neuropathogenesis of this human infection. This review will compare and contrast different murine models in the context of available information from human studies of CNS disease following congenital HCMV infections.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathogens
Numberingvol. 10, no. 8, 1062
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens10081062
URN:NBNurn:nbn:hr:184:156194
Publication2021-08-21
ProjectNumber: KK.01.1.1.01.0006
Title (english): Strengthening the capacity of CerVirVac for research in virus immunology and vaccinology
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttps://www.mdpi.com/2076-0817/10/8/1062
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-09-17 12:45:49