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master's thesis
Uloga kalpaina u bolestima srčanog mišića
2021. urn:nbn:hr:184:908825
Vidaić, Vedrana
University of Rijeka
Faculty of Medicine
Department of General Pathology and Pathological Anatomy

Cite this document

Vidaić, V. (2021). Uloga kalpaina u bolestima srčanog mišića (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:908825

Vidaić, Vedrana. "Uloga kalpaina u bolestima srčanog mišića." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:908825

Vidaić, Vedrana. "Uloga kalpaina u bolestima srčanog mišića." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:908825

Vidaić, V. (2021). 'Uloga kalpaina u bolestima srčanog mišića', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 05 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:908825

Vidaić V. Uloga kalpaina u bolestima srčanog mišića [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2021 [cited 2024 December 05] Available at: https://urn.nsk.hr/urn:nbn:hr:184:908825

V. Vidaić, "Uloga kalpaina u bolestima srčanog mišića", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:184:908825

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Metadata
TitleUloga kalpaina u bolestima srčanog mišića
Title (english)The role of calpain in the heart muscle diseases
AuthorVedrana Vidaić
MentorKoviljka Matušan-Ilijaš (mentor)
Committee memberEmina Babarović (predsjednik povjerenstva)
Committee memberIta Hadžisejdić (član povjerenstva)
Committee memberNatalia Kučić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Rijeka
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract
Bolesti miokarda, ponajprije ishemijska srčana bolest, veliki su javnozdravstveni problem u svijetu i vodeći uzrok smrti u većini razvijenih zemalja svijeta. U posljednjih 30-ak godina broj smrtnih slučajeva od IHD u tim zemljama se smanjio, ali u mnogim dijelovima svijeta taj broj i dalje raste (Rusija i neke istočnoeuropske zemlje). Mogućnost da sustav kalpaina igra ulogu u ovim bolestima eksperimentalno je istražena u literaturi i neke studije su se fokusirale na efekte inhibicije kalpaina u poboljšanju disfunkcije miokarda. Kalpaini su skupina nelizosomskih cisteinskih proteaza koji se aktiviraju u prisutnosti kalcija. Nekontrolirana aktivnost kalpaina povezana je s patogenezom reperfuzijske ozljede miokarda, hipertrofije miokarda, srčanog zastoja i ishemije miokarda. Inhibicija kalpaina može znatno usporiti proces zatajivanja srca i reducirati veličinu infarkta nakon ishemije-reperfuzije. Pretjerana aktivacija kalpaina igra ulogu u oštećenju mitohondrija i oksidativnoj fosforilaciji za vrijeme IRI. Stoga inhibicija kalpaina predstavlja potencijalnu terapijsku strategiju u liječenju bolesti miokarda.
Abstract (english)
Miocardial diseases, primarily IHD, are a major public health problem worldwide and leading cause of death in the most developed countries. In the last thirty years the number of deaths from IHD has decreased, but in many parts of the world this number continues to grow (Russia and some Eastern European countries). The possibility that the calpain system could play a role in these deseases has been experimentally investigated in the literature and several studies have focused on the effects of calpain inhibitors in improving myocardial dysfunction. Calpains are a group of non-lysosomal calcium-activated cystein proteases. Uncontrolled activation of calpain has been found to be involved in the pathogenesis of IRI, cardiac hypertrophy, myocardial stunning and cardiac ischemia. Calpain inhibition significanty attenuate myocardial stunning and reduced infarct size after ischemia-reperfusion. Calpain inhibition therefore serves as a potential medical therapy for patients suffering of myocardial diseases.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:908825
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-07-11 17:12:48