Kawasaki disease is a multisystem disease of unknown etiology. It is characterized by a typical clinical presentation - fever, rash, bilateral nonexudative conjunctivitis, cervical lymphadenitis, changes of the extremities, hyperemia of mucous membranes of the mouth, dry lips and/or tongue, strawberry tongue. The most serious complication is the development of aneurysms of the coronary vessels whose incidence decreased after the introduction of immunoglobulin and aspirin as therapy. In the period from 2011 to 2015 at the Department of Pediatrics at KBC Rijeka, six children were hospitalized due to Kawasaki disease. There were 2 boys and 4 girls. The median age was 27.5 months. Clinical criteria - fever, rash, conjunctivitis and changes in the mouth had all children, while changes on the extremities and neck lymphadenitis were present in five children. Among other symptoms, arthritis was recorded in one case and vomiting in 2 children. Erythema and induration at the site of BCG scar was described with 2 children. Positive meningeal signs had one child. ECG and echocardiography showed no pathological findings in any child. All children were treated with immunoglobulin therapy and high-dose aspirin. Average salicylate therapy was conducted for 70 days. Side effects of immunoglobulin were observed in one child. All the patients healed without consequences.