The adrenal gland is even enocrine gland that is located above left and right kidney.It is made of two parts,the cortex and the medulla.The cortex secretes glucocorticoids, mineralocorticoids and adrenal androgens.The medulla secretes catecholamines. Adrenal gland disorders are divided in hypoadrenocorticism and hyperadrenocorticism. Hypoadrenocotricism is characterized with decreased secretion of any hormone from adrenal cortex.The most important disorders in which hypoadrenocorticism is presented are congenital adrenal hypoplasia/aplasia,congenital adrenal hyperplasia,adrenal hemorrhage, hypofunction caused by infection,Addison's disease and noninfectious disorders and adrenal tumors.Hyperadrenocorticism is characterized with increased secretion of any hormone from adrenal cortex and it is divided in hypercotrisolism,hyperaldosteronism,virilized adrenal tumors and feminizing adrenal tumors.Clinical manifestation depends on which hormone is increased or decreased.Diagnosis is based on dereminizing hormone concentration in plasma ot its metabolites in urine.Imaging diagnostics(US,CT or MRI) is very important for diagnosing disorders caused by tumor.Therapy of hypoadrenocorticism includes synthetic glucocorticoids and if needed mineralocorticoids and androgens.In disorders caused by nonfunctional tumor, therapy is surgical.Therapy of hyperadrenocorticism includes resolving the cause of it. The most common disorders occuring in adrenal medulla in children are tumors.The most important are pheochromocytoma and neuroblastoma.Clinical manifestation is characterized with different symptoms depending on size and localization of tumor.In pheochromocytoma and neuroblastoma the secretion of catecholamines is increased.Diagnosis is based on determinizing hormone concentration in plasma and its metabolites in urine.Imaging diagnostics(CT or MRI) is very impotrant.Therapy is surgical.